Special Issue "Transmembrane and Intracellular Translocation of Activator Ca Ions in Cardiac and Smooth Muscle Cells"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (15 February 2021).
Special Issue Editor
Interests: Physiology and biochemistry of skeletal; cardiac and smooth muscle myosins in health and in disease; Compartive aspects of physiology and biochemistry of muscle and mechanism of locomotion; primitive; Role of myosins in primitive motile systems; such as amoevoid movement; contractile ring formation; and other cellulr motile functions
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Special Issue Information
It has been well established that muscle contraction results from the elevation of free Ca ion concentration in the interior of muscle cells [Ca2+]i. The Ca2+ producing contraction is called the activator Ca ion.
In cardiac muscle cells, it is generally believed that activator Ca comes from the extracellular fluid in the form of an inward Ca current across the surface membrane, and it is regulated by the Na–Ca exchange mechanism. It has been shown, however, that activator Ca also comes from internal Ca accumulation structures, as indicated by so-called Ca-sparks and recorded by Ca-indicators in relaxed cardiac muscle cells.
In various smooth muscle cells, on the other hand, it has been shown microscopically that activator Ca is stored in internal membrane structures.
This Special Issue on “Transmembrane and Intracellular Translocation of Activator Ca Ions in Cardiac and Smooth Muscle Cells” aims to gather papers addressing the abovementioned topics.
Dr. Haruo Sugi
Guest Editor
Manuscript Submission Information
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