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Conserved Pathways in Development and Cancer
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Conserved Pathways in Development and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 3780

Special Issue Editors

Dr. Tomasz Wilanowski

E-Mail Website
Guest Editor
Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw, Poland
Interests: transcription factors; Grainyhead-like; regulation of gene expression; oncogenes; tumor suppressors; drug targets; phosphorylation; post-translational modifications; skin cancer; renal cancer; somatic mutations in cancer; polymorphisms including single nucleotide polymorphisms; mammalian embryonic development
Special Issues, Collections and Topics in MDPI journals
Dr. Seb Dworkin

E-Mail Website
Guest Editor
Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC 3086, Australia
Interests: transcription factors; Grainyhead-like; skin cancer; brain cancer; mammalian embryonic development; lung morphogenesis; zebrafish embryonic development; craniofacial development; brain development; neurogenesis; epidermal disorders; wound healing
Special Issues, Collections and Topics in MDPI journals
Dr. Charbel Darido

E-Mail Website
Guest Editor
The Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia
Interests: squamous cell carcinoma; skin; head and neck; mouse models; oncogenic networks; prevention; treatment; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Normal embryonic development is governed by genetic pathways that control a myriad of processes, ranging from cell division, migration and differentiation, to organ formation. These pathways are often co-opted and de-regulated in common diseases of adulthood, including the progression of cancer. Many parallels exist between the normal cellular process required for the establishment of an embryo (such as asymmetric cell division in stem cells, epithelial to mesenchymal transitions in organ establishment, and formation of the vascular system required) with identical pathways that drive tumour initiation and progression. In effect, tumour growth can in many cases be thought of as the aberrant establishment of a new "organ" (Gerlitz et al., EMBO Reports 9: 730-734), utilising and corrupting precisely the same conserved genetic pathways required for normal growth. This special issue is devoted to understanding these parallels; by determining the normal pathways of tissue and organ establishment, we can better understand the consequences of their deregulation in the context of cancer development.

Dr. Tomasz Wilanowski
Dr. Seb Dworkin
Dr. Charbel Darido
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Development
  • Proliferation
  • Embryogenesis
  • Angiogenesis
  • Epithelial-Mesenchymal Transition (EMT)
  • Stem Cells
  • Migration
  • Differentiation
  • De-differentiation

Published Papers (1 paper)

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Review

35 pages, 4855 KiB  
Review
Grainyhead-like (Grhl) Target Genes in Development and Cancer
by Jemma G. Gasperoni, Jarrad N. Fuller, Charbel Darido, Tomasz Wilanowski and Sebastian Dworkin
Int. J. Mol. Sci. 2022, 23(5), 2735; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23052735 - 01 Mar 2022
Cited by 7 | Viewed by 3193
Abstract
Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs) that regulate processes common to both natural cellular behaviours during embryogenesis, and de-regulation of growth and survival pathways in cancer. Serving to drive the transcription, and therefore activation of multiple co-ordinating pathways, the [...] Read more.
Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs) that regulate processes common to both natural cellular behaviours during embryogenesis, and de-regulation of growth and survival pathways in cancer. Serving to drive the transcription, and therefore activation of multiple co-ordinating pathways, the three GRHL family members (GRHL1-3) are a critical conduit for modulating the molecular landscape that guides cellular decision-making processes during proliferation, epithelial-mesenchymal transition (EMT) and migration. Animal models and in vitro approaches harbouring GRHL loss or gain-of-function are key research tools to understanding gene function, which gives confidence that resultant phenotypes and cellular behaviours may be translatable to humans. Critically, identifying and characterising the target genes to which these factors bind is also essential, as they allow us to discover and understand novel genetic pathways that could ultimately be used as targets for disease diagnosis, drug discovery and therapeutic strategies. GRHL1-3 and their transcriptional targets have been shown to drive comparable cellular processes in Drosophila, C. elegans, zebrafish and mice, and have recently also been implicated in the aetiology and/or progression of a number of human congenital disorders and cancers of epithelial origin. In this review, we will summarise the state of knowledge pertaining to the role of the GRHL family target genes in both development and cancer, primarily through understanding the genetic pathways transcriptionally regulated by these factors across disparate disease contexts. Full article
(This article belongs to the Special Issue Conserved Pathways in Development and Cancer)
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