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Special Issue "Translational Research and Drug Repurposing: Targeting Cancer Energy Metabolism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Wojciech M. Fendler
E-Mail Website
Guest Editor
Department of Biostatistics and Translational Medicine, Medical University of Lodz, 90-419 Lodz, Poland
Interests: biomarkers; diabetes; radiation oncology; microRNA

Special Issue Information

Dear Colleagues,

Reprogramming of the cellular energy metabolism to support constant growth, division and metastasis is a hallmark of cancer. A common metabolic switch in cancer cells, the Warburg effect, favors glycolysis over oxidative phosphorylation, even in fully aerobic conditions, facilitating the anabolic processes required to support proliferation. Mutated oncogenes, including MYC and RAS, directly regulate signaling pathways and enzymes, altering metabolic requirements and tumor growth. These alterations may be induced directly by mutations or by epigenetic mechanisms and changes in signal transduction that are frequently promoted by the tumor microenvironment and may lead to increased cancer heterogeneity and treatment resistance. Deeper understanding of the metabolic changes that promote cancer initiation and growth is required to identify novel targets and design strategies to overcome the obstacles to successful therapy. With technological advances that have led to the creation of datasets of cellular signatures induced by pharmacologic perturbations, such as Connectivity Map, the opportunities for informed drug repurposing have dramatically expanded.

The focus of this Special Issue is cancer energy metabolism. We will welcome original research, including basic and translational studies, as well as review articles, focused on challenges in targeting the cancer cell metabolism. We especially invite papers focused on the strategies of repurposing existing drugs to leverage the metabolic alterations and improve patient survival.

Dr. Wojciech M. Fendler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • metabolism
  • glycolysis
  • mitochondria
  • drug repurposing
  • hypoxia

Published Papers

This special issue is now open for submission.
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