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Cell Signalling in Cancer: Organelles and Beyond
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Cell Signalling in Cancer: Organelles and Beyond

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 10695

Special Issue Editors

Dr. Marta Giacomello

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Guest Editor
Department of Biology and Department of Biomedical Sciences, University of Padova, Padova, Italy
Interests: organelles crosstalk; fluorescent proteins; high throughput screens; autism spectrum disorders
Dr. Agnese De Mario

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Guest Editor
Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Interests: Intracellular Calcium homeostasis; Mitochondrial calcium signaling in health and disease; organelles crosstalk
Dr. Caterina Vianello

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Guest Editor
Department of Biology, University of Padova, 35131 Padova, Italy
Interests: Cancer; Mitochondria; Inter-organelle contact sites

Special Issue Information

Dear Colleagues,

Cell signalling is profoundly rewired in tumorigenesis. Changes in cell metabolism, cell growth and division, Ca2+ homeostasis, autophagy and redox signalling are just a few examples of the complex and heterogeneous cellular hallmarks that characterize different types of cancer. Intracellular organelles, especially the mitochondria, play fundamental roles in the reprogramming of cancer cells to adapt to different stressors and new energetic needs. Their interaction also emerges as an important hub at which different pathways convey, thereby leading to the concerted and coordinated rewiring of organelle activities.

The aim of this Special Issue is to bring into focus how intracellular organelles, either individually or together, orchestrate the signal transduction pathways that sustain tumour onset and progression as well as metastasization. Thus, all researchers interested in the cell signalling and molecular mechanisms underlying cancer pathogenesis are welcome to submit their original work or reviews to this Special Issue.

Dr. Marta Giacomello
Dr. Agnese De Mario
Dr. Caterina Vianello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cancer
  • Organelles crosstalk
  • Cell signalling
  • Contact sites
  • Cancer metabolism
  • Calcium signalling
  • Lipid homeostasis
  • Mitochondria
  • Apoptosis
  • Autophagy
  • Mitophagy
  • Cellular stress responses

Published Papers (2 papers)

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Review

21 pages, 1652 KiB  
Review
Calcium Signalling in Breast Cancer Associated Bone Pain
by Andrea Bortolin, Estrela Neto and Meriem Lamghari
Int. J. Mol. Sci. 2022, 23(3), 1902; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23031902 - 08 Feb 2022
Cited by 5 | Viewed by 3896
Abstract
Calcium (Ca2+) is involved as a signalling mediator in a broad variety of physiological processes. Some of the fastest responses in human body like neuronal action potential firing, to the slowest gene transcriptional regulation processes are controlled by pathways involving calcium [...] Read more.
Calcium (Ca2+) is involved as a signalling mediator in a broad variety of physiological processes. Some of the fastest responses in human body like neuronal action potential firing, to the slowest gene transcriptional regulation processes are controlled by pathways involving calcium signalling. Under pathological conditions these mechanisms are also involved in tumoral cells reprogramming, resulting in the altered expression of genes associated with cell proliferation, metastatisation and homing to the secondary metastatic site. On the other hand, calcium exerts a central function in nociception, from cues sensing in distal neurons, to signal modulation and interpretation in the central nervous system leading, in pathological conditions, to hyperalgesia, allodynia and pain chronicization. It is well known the relationship between cancer and pain when tumoral metastatic cells settle in the bones, especially in late breast cancer stage, where they alter the bone micro-environment leading to bone lesions and resulting in pain refractory to the conventional analgesic therapies. The purpose of this review is to address the Ca2+ signalling mechanisms involved in cancer cell metastatisation as well as the function of the same signalling tools in pain regulation and transmission. Finally, the possible interactions between these two cells types cohabiting the same Ca2+ rich environment will be further explored attempting to highlight new possible therapeutical targets. Full article
(This article belongs to the Special Issue Cell Signalling in Cancer: Organelles and Beyond)
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17 pages, 1569 KiB  
Review
Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma
by Steven He, Rajdeep Chakraborty and Shoba Ranganathan
Int. J. Mol. Sci. 2022, 23(3), 1562; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23031562 - 29 Jan 2022
Cited by 25 | Viewed by 6172
Abstract
Oral cancer is the most common form of head and neck squamous cell carcinoma (HNSCC) and most frequently presents as oral squamous cell carcinoma (OSCC), which is associated with an alarmingly high mortality rate. Internationally, a plethora of research to further our understanding [...] Read more.
Oral cancer is the most common form of head and neck squamous cell carcinoma (HNSCC) and most frequently presents as oral squamous cell carcinoma (OSCC), which is associated with an alarmingly high mortality rate. Internationally, a plethora of research to further our understanding of the molecular pathways related to oral cancer is performed. This research is of value for early diagnosis, prognosis, and the investigation of new drugs that can ameliorate the harmful effects of oral cancer and provide optimal patient outcomes with minimal long-term complications. Two pathways on which the progression of OSCC depends on are those of proliferation and apoptosis, which overlap at many junctions. Herein, we aim to review these pathways and factors related to OSCC progression. Publicly available search engines, PubMed and Google Scholar, were used with the following keywords to identify relevant literature: oral cancer, proliferation, proliferation factors, genes, mutations, and tumor suppressor. We anticipate that the use of information provided through this review will further progress translational cancer research work in the field of oral cancer. Full article
(This article belongs to the Special Issue Cell Signalling in Cancer: Organelles and Beyond)
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