Special Issue "Advances in Cancer Stem Cells"
Deadline for manuscript submissions: 31 December 2021.
Interests: stem cells; oxygen; inflammation; clinical physiology; critical care; emergency medicine
Cancer stem cells (CSCs) have been a medical subject term in the U.S. National Library of Medicine since 2008 (neoplastic stem cells). CSCs are characterized as highly proliferative, self-renewing cells, which can form colonies and give rise to neoplasms. Therapy for most neoplasms starts with surgical removal of the neoplasm forming a malignant tumor. Frequently, residual cancer cells including CSCs are treated by additional chemo- and/or immunotherapy. CSCs with changes like epithelial-mesenchymal transition (EMT) are seen as the main reason for the formation of metastasis, but mostly escape current treatments due to their quiescent status and metabolism with high resistance to chemotherapy and immune escape mechanisms. Here, we will review CSCs in a bottom-up approach starting from tumor surgery to cell biology of CSCs and discuss advances in understanding signaling pathways. These might include Notch, WNT, Hedgehog, and the Hippo pathway. Furthermore, inflammation-related signaling impinging on transcription factors like NF-kappaB or MYC will be discussed. Similarities and differences of CSCs from different organs such as the brain, lung, reproductive tract, and digestive system will be taken into account. Advancements of CSCs within precision medicine will be reviewed, with cultured CSCs as a potential screening system for drug treatment, complementing surgery.
We would like to invite you to contribute reviews and/or original work for a Special Issue on “Advances in Cancer Stem Cells”. It would be a pleasure to receive a contribution from you.
Prof. Dr. Fritz Mertzlufft
Prof. Dr. Christian Kaltschmidt
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- cancer stem cells
- tumor-initiating cells
- neoplastic stem cells