Special Issue "Molecular Drivers of Responsiveness to Cancer Immunotherapy"
Deadline for manuscript submissions: 31 October 2021.
Interests: mechanisms of immunosuppression; cannabinoid receptors; tumor immunology; anti-cancer vaccines; immunotherapeutics; immunosuppressive myeloid cells (MDSC)
Interests: tumor immunology; immunotherapy resistance; immune monitoring
Cancer immunotherapeutics such as cancer vaccines and immune checkpoint inhibitors act by activating the immune system against cancer. Despite recent advances and encouraging successes, the pressing problem is the resistance to these treatments in the majority of patients; for example, only <10–15% of patients respond to checkpoint inhibitors such as anti-PD-1 and anti-CTLA-4. Therefore, understanding the mechanisms of resistance to immunotherapy as well as developing treatments to overcome resistance and improve responsiveness are critical areas of research. This Special Issue of the International Journal of Molecular Sciences will discuss emerging concepts in these areas. The topics will encompass molecular and cellular mechanisms of resistance to checkpoint blockade and anti-tumor vaccines, innate and acquired resistance, pathways of immunosuppression including suppressor cell populations, and approaches combining chemo-radiation or other targeted treatments to improve immunotherapy responsiveness and overall efficacy.
Dr. Venkatesh Hegde
Dr. Stephanie M. Dorta-Estremera
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cancer vaccines
- checkpoint blockade
- cytokines and chemokines
- immunotherapy resistance
- suppressor cells