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Special Issue "New Insights into Cardiac Ion Channel Regulation 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Brian P. Delisle
E-Mail Website
Guest Editor
Department of Physiology, University of Kentucky, Lexington, KY, USA
Interests: genetics; ion channel; protein trafficking; cardiac arrhythmia; chronobiology; protein structure and function
Special Issues, Collections and Topics in MDPI journals
Dr. Ademuyiwa Aromolaran
E-Mail Website
Guest Editor
Department of Surgery, Division of Cardiothoracic Surgery, Molecular Medicine Program, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA
Interests: cardiac electrophysiology; ion channel biophysics; arrhythmias; inflammation and metabolic disorders

Special Issue Information

Dear Colleagues,

The ordered electrical excitation of the heart coordinates the efficient pumping of blood throughout the body. Cardiac arrhythmias are electrical disturbances that are often the manifestation of drug toxicity or acquired or genetic diseases. Clinicians and scientists collectively work to identify the basis and prevention of different arrhythmogenic mechanisms. Molecular, cellular, animal, and clinical studies have identified several major families of clinically important cardiac ionic currents and their associated genes and proteins. These studies have led to new discoveries in ion channel regulation at the level of gene transcription, mRNA splicing and stability, translation, protein assembly, intracellular transport (trafficking), second messenger modification, and biophysical function. In this Special Issue, we focus on foundational and emerging concepts in cardiac ion channel regulation, with an emphasis on how this information contributes to a better understanding of normal cardiac excitation and arrhythmogenicity.

Dr. Brian P. Delisle
Dr. Ademuyiwa Aromolaran
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (1 paper)

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Macrophage-Dependent Interleukin-6-Production and Inhibition of IK Contributes to Acquired QT Prolongation in Lipotoxic Guinea Pig Heart
Int. J. Mol. Sci. 2021, 22(20), 11249; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011249 - 18 Oct 2021
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In the heart, the delayed rectifier K current, IK, composed of the rapid (IKr) and slow (IKs) components contributes prominently to normal cardiac repolarization. In lipotoxicity, chronic elevation of pro-inflammatory cytokines may remodel IK [...] Read more.
In the heart, the delayed rectifier K current, IK, composed of the rapid (IKr) and slow (IKs) components contributes prominently to normal cardiac repolarization. In lipotoxicity, chronic elevation of pro-inflammatory cytokines may remodel IK, elevating the risk for ventricular arrythmias and sudden cardiac death. We investigated whether and how the pro-inflammatory interleukin-6 altered IK in the heart, using electrophysiology to evaluate changes in IK in adult guinea pig ventricular myocytes. We found that palmitic acid (a potent inducer of lipotoxicity), induced a rapid (~24 h) and significant increase in IL-6 in RAW264.7 cells. PA-diet fed guinea pigs displayed a severely prolonged QT interval when compared to low-fat diet fed controls. Exposure to isoproterenol induced torsade de pointes, and ventricular fibrillation in lipotoxic guinea pigs. Pre-exposure to IL-6 with the soluble IL-6 receptor produced a profound depression of IKr and IKs densities, prolonged action potential duration, and impaired mitochondrial ATP production. Only with the inhibition of IKr did a proarrhythmic phenotype of IKs depression emerge, manifested as a further prolongation of action potential duration and QT interval. Our data offer unique mechanistic insights with implications for pathological QT interval in patients and vulnerability to fatal arrhythmias. Full article
(This article belongs to the Special Issue New Insights into Cardiac Ion Channel Regulation 2.0)
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