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Cardiometabolic and Cardiotoxicity Disorders
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Cardiometabolic and Cardiotoxicity Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 5653

Special Issue Editor

Dr. María Galán

E-Mail Website
Guest Editor
Group of Regulatory Mechanisms in Cardiovascular Remodeling, Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Sant Antoni MªClaret, 167, 08025 Barcelona, Spain
Interests: cardiovascular remodeling; hypertension; aortic disease; heart hypertrophy; diabetes; endoplasmic reticulum stress; mitochondrial stress; cardiotoxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiometabolic disorders are grouped as a disease entity called cardiometabolic syndrome (CMS). The underlying pathophysiology is formed by a combination of maladaptive cardiovascular, renal, metabolic, prothrombotic, and inflammatory abnormalities. These alterations individually and interdependently lead to a substantial increase in cardiovascular disease (CVD) morbidity and mortality. Indeed, people with cardiometabolic syndrome are two times more likely to die from coronary heart disease and three times more likely to have heart attack and stroke. Cardiomyopathy may be caused not only by long-standing high blood pressure or diabetes, but also by other pathological conditions such as viral or bacterial infections, alcoholism, hyperthyroidism, or amyloidosis that lead to damaged heart muscle. In addition, cardiomyopathy is also caused by cardiotoxicity as the result of treatments, such as chemotherapeutic medications or other medications to control disease.

This Special Issue will bring together original research and review articles on cardiovascular research related to cardiometabolic and cardiotoxic disorders. It is focused on the study of the dysregulation of signal transduction pathways involved in cardiometabolic alterations and will present new discoveries, therapeutic approaches, and technical developments in molecular cardiovascular research that can advance our understanding of cardiovascular disease development and its associated risk factors.

Dr. María Galán
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cardiokines
  • Diabetes
  • Obesity
  • Hypertension
  • Dyslipidemia
  • Cardiotoxicity
  • Immunomodulation
  • Systemic inflammation
  • Mitochondrial dysfunction
  • Metabolomics
  • Lipotoxicity

Published Papers (2 papers)

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Research

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14 pages, 2743 KiB  
Article
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality
by Jaime Lasheras, Rosario Pardo, Marc Velilla, Marcos Poncelas, Núria Salvatella, Rafael Simó, Marisol Ruiz-Meana, Mònica Zamora and Josep A. Villena
Int. J. Mol. Sci. 2021, 22(15), 8047; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158047 - 28 Jul 2021
Cited by 7 | Viewed by 2459
Abstract
Proper cardiac function depends on the coordinated expression of multiple gene networks related to fuel utilization and mitochondrial ATP production, heart contraction, and ion transport. Key transcriptional regulators that regulate these gene networks have been identified. Among them, estrogen-related receptors (ERRs) have emerged [...] Read more.
Proper cardiac function depends on the coordinated expression of multiple gene networks related to fuel utilization and mitochondrial ATP production, heart contraction, and ion transport. Key transcriptional regulators that regulate these gene networks have been identified. Among them, estrogen-related receptors (ERRs) have emerged as crucial modulators of cardiac function by regulating cellular metabolism and contraction machinery. Consistent with this role, lack of ERRα or ERRγ results in cardiac derangements that lead to functional maladaptation in response to increased workload. Interestingly, metabolic inflexibility associated with diabetic cardiomyopathy has been recently associated with increased mitochondrial fatty acid oxidation and expression of ERRγ, suggesting that sustained expression of this nuclear receptor could result in a cardiac pathogenic outcome. Here, we describe the generation of mice with cardiac-specific overexpression of ERRγ, which die at young ages due to heart failure. ERRγ transgenic mice show signs of dilated cardiomyopathy associated with cardiomyocyte hypertrophy, increased cell death, and fibrosis. Our results suggest that ERRγ could play a role in mediating cardiac pathogenic responses. Full article
(This article belongs to the Special Issue Cardiometabolic and Cardiotoxicity Disorders)
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Review

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26 pages, 4533 KiB  
Review
Mitochondrial Dysfunction in the Cardio-Renal Axis
by Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega and Sandra Rayego-Mateos
Int. J. Mol. Sci. 2023, 24(9), 8209; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24098209 - 03 May 2023
Cited by 3 | Viewed by 2429
Abstract
Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of [...] Read more.
Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mitochondrial dysfunction in cardiovascular and renal diseases, suggesting that maintaining mitochondrial homeostasis is a promising therapeutic strategy for CRS. In this review, we explore the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and how it contributes to the development and progression of the main vascular pathologies that could be affected by kidney injury and vice versa, and how this knowledge may guide the development of novel therapeutic strategies in CRS. Full article
(This article belongs to the Special Issue Cardiometabolic and Cardiotoxicity Disorders)
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