Special Issue "Cardiotonic Steroids: From Toxins to Hormones"
Deadline for manuscript submissions: closed (28 February 2021).
Interests: salt-sensitive hypertension; preeclampsia; chronic renal failure; Na/K-ATPase inhibitors; endogenous cardiotonic steroids; marinobufagenin; antibody to marinobufagenin; immunotherapy: gene expression; fibrosis
Interests: cardiotonic steroids; Na/K-ATPase inhibitors; marinobufagenin; gene expression; growth factors; arterial wall diseases; fibrosis; vascular dementia; Alzheimer’s disease; salt-sensitive hypertension; chronic kidney disease; aging
Cardiotonic steroids (CS), obtained from plants such as Digitalis purpurea and Strophanthus, and animals like toad Bufo Marinus, were once widely used components of traditional medicine. The use of CS ouabain by Skou in the discovery of Na/K-ATPase consolidated the function of CS as inhibitors and regulators of Na/K-ATPase, opening a new era in the studies of these steroidal agents. Several decades later, the endogenous forms of CS were discovered in mammals, specifically in humans and rodents. Numerous important findings and discoveries have been made since then. While our understanding of the CT function is still incomplete, the importance of this class of hormones is considerable. Endogenous CS were found to be mostly presented by cardenolides, like ouabain, and bufadienolides, such as marinobufagenin and telocinobufagin. CS functions include not only the inhibition of Na/K-ATPase, and regulation of the monovalent ions balance and cell homeostasis, but also the initiation of multisignal cascade transduction pathways. By binding to the Na pump ,CS can affect cell growth and differentiation, apoptosis and proliferation, glucose metabolism, and control of central nervous functions. Dysregulation of CS plays an important role in multiple diseases, including chronic kidney disease, cancer, preeclampsia, hypertension, and other cardiovascular disorders. The understanding of this class of hormones will lead to the discovery of the novel therapeutic strategies in the regulation of physiological functions and in curing diseases. The present Special Issue on “Cardiotonic Steroids” is dedicated to the recent findings related to a multifaceted role of these incredible molecules in health and disease.
Dr. Alexei Y. Bagrov
Dr. Olga Fedorova
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- cardiotonic steroids
- physiological and pathological function