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Special Issue "Cellular Structural Biology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Ana Joaquina Perez-Berna
E-Mail Website
Guest Editor
MISTRAL Beamline, ALBA-CELLS Synchrotron, Barcelona, Spain
Interests: virology; structural and cellular biology; cryo soft X-ray tomography

Special Issue Information

Dear Colleagues,

The possibility of describing a complete and intact cell with sufficient resolution so as to define its structural components in a fully quantitative way is a major goal in life sciences, with obvious impact on health and on the design of new biomaterials.

In this context, cryo-soft X-ray tomography represents an interesting technique to retrieve information at nanometer resolution, covering full cellular volumes near to native state. Indeed, the high resolution of this technique allows the visualization of the structural organization of cells, their membranes, compartments, organelles and supramolecular assemblies, which makes this method one of the most exciting alternatives to image complete biological cells.

To reflect these advances, the International Journal of Molecular Sciences has designed a Special Issue that is accepting contributions with an emphasis on biophysics, imaging and structural biology, and their integration to provide a view of the cell at multiple scales.

Dr. Ana Joaquina Perez-Berna
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • virology
  • structural biology
  • cellular biology
  • cellular infection
  • cellular genetic disease
  • cryo-soft X-ray tomography
  • correlative visible light
  • cancer cells
  • nanoparticles
  • cellular therapy
  • cellular differentiation
  • gene-editing monitoring

Published Papers (1 paper)

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Research

Article
Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells
Int. J. Mol. Sci. 2021, 22(18), 9680; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189680 - 07 Sep 2021
Viewed by 412
Abstract
Type 1 tunneling nanotubes (TNTs-1) are long, cytoplasmic protrusions containing actin, microtubules and intermediate filaments that provide a bi-directional road for the transport of various components between distant cells. TNT-1 formation is accompanied by dramatic cytoskeletal reorganization offering mechanical support for intercellular communication. [...] Read more.
Type 1 tunneling nanotubes (TNTs-1) are long, cytoplasmic protrusions containing actin, microtubules and intermediate filaments that provide a bi-directional road for the transport of various components between distant cells. TNT-1 formation is accompanied by dramatic cytoskeletal reorganization offering mechanical support for intercellular communication. Although the centrosome is the major microtubule nucleating center and also a signaling hub, the relationship between the centrosome and TNTs-1 is still unexplored. We provide here the first evidence of centrosome localization and orientation towards the TNTs-1 protrusion site, which is implicated in TNT-1 formation. We also envision a model whereby synchronized reorientation of the Golgi apparatus along with the centrosome towards TNTs-1 ensures effective polarized trafficking through TNTs-1. Furthermore, using immunohistochemistry and live imaging, we observed for the first time the movement of an extra centrosome within TNTs-1. In this regard, we hypothesize a novel role for TNTs-1 as a critical pathway serving to displace extra centrosomes and potentially to either protect malignant cells against aberrant centrosome amplification or contribute to altering cells in the tumor environment. Indeed, we have observed the increase in binucleation and proliferation markers in receiving cells. The fact that the centrosome can be both as the base and the user of TNTs-1 offers new perspectives and new opportunities to follow in order to improve our knowledge of the pathophysiological mechanisms under TNT control. Full article
(This article belongs to the Special Issue Cellular Structural Biology)
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