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Special Issue "Cellular Synchrony in Disease and Health"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Bojlul Bahar
E-Mail Website
Guest Editor
School of Sport and Health Sciences, University of Central Lancashire, Preston PR1 2HE, UK
Interests: metabolic syndrome; insulin resistance; obesity; tyep-2 diabetes; metabolic inflammation; chrononutrition; molecular nutrition

Special Issue Information

Dear Colleagues,

Multicellular organisms have different organs and tissues with a structurally and functionally diverse population of cells.  It is plausible to expect that the cellular response to stimuli (nutrients, drugs, toxins and xenobiotics, light, radiation etc.) within the cell population representing an organ system/tissue may or may not be identical. The presence of functional asynchrony within an otherwise morphological homogenous cell population is reported in the literature.

Intuitively, a population of metabolically synchronized cells present within the tissue would handle external stimuli more efficiently than that of asynchronized cells. The functional asynchrony of cells could potentially weaken the collective metabolic response to oxidative stress and inflammatory challenges commonly found in human diseases, such as cancer, type 2 diabetes, and neurodegenerative diseases. For instance, the circadian locomotor output cycles kaput (CLOCK) gene that encodes a basic helix-loop-helix-PAS transcription factor helps one to attain synchrony in mammalian circadian rhythmicity at the cell, tissue, organ and whole organism level.  However, the molecular mechanism underlying the attainment of cell synchrony at the gene transcription, translation and post-translational levels is yet to be fully understood.

This Special Issue of International Journal of Molecular Sciences will showcase original research on the mechanisms of metabolic and functional synchrony in mammalian cells in the context of chronic disease models.

Topics of interest to this Special Issue include, but are not limited to:

  1. Metabolic asynchrony and oxidative stress
  2. Cellular synchrony and the pathology of chronic inflammatory diseases
  3. Biomarkers of the assessment of cellular synchrony
  4. Interaction of cell stimuli (drugs, nutrients, toxins, radiation) causing synchrony or asynchrony in cell metabolism, including underlying biochemical pathways
  5. Induction of cell synchrony through various agents
  6. Role of circadian rhythmicity (local and central) on cellular synchrony at the cell, tissue, organ and organism level

In addition, review articles on pharmacological and nutritional approaches, achieving cell synchrony and metabolism and the management of chronic inflammatory diseases are also welcomed.

Dr. Bojlul Bahar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cellular synchrony
  • oxidative stress
  • chronic inflammatory diseases
  • interaction
  • metabolism

Published Papers

This special issue is now open for submission.
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