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Special Issue "Cholinergic Control of Inflammation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Roberta Benfante
E-Mail Website
Guest Editor
CNR-Neuroscience Institute, c/o University of Milano Bicocca – Ed.28 –Via Raoul Follereau,3, 20854 Vedano al Lambro (MB), Italy
Interests: Gene expression; Nicotinic Acetylcholine Receptor (nAChR); Pharmacogenetics and pharmacogenomics in neuronal diseases; Inflammation; Alzheimer's disease; Neuroblastoma; Autonomic Nervous System Development

Special Issue Information

Dear Colleagues,

The International Journal of Molecular Sciences is publishing a Special Issue entitled "Cholinergic Control of Inflammation". Over the last 20 years, autonomic regulation of local and systemic inflammation through the "cholinergic anti-inflammatory pathway" has been increasingly recognized as playing an important role in several areas, including neurodegenerative diseases (AD and PD), metabolic syndrome, and autoimmune diseases. As Guest Editor, I would be very pleased if you would contribute to this issue with either an original research paper or a focused review with an emphasis on the molecular mechanisms that regulate the cholinergic response to inflammation, their pathological deregulation, and potential therapeutic applications. Contributions concerning the cholinergic system and COVID-19 are also welcome.

Dr. Roberta Benfante
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cholinergic system
  • Inflammation
  • Innate immunity
  • Alpha-7 nicotinic receptor
  • Muscarinic receptor
  • Agonists/antagonists
  • Acetylcholine esterase
  • Gene expression
  • Epigenetics
  • Neuroinflammation

Published Papers (1 paper)

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Review

Open AccessReview
Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor
by , , and
Int. J. Mol. Sci. 2021, 22(9), 4912; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094912 (registering DOI) - 06 May 2021
Viewed by 35
Abstract
All nervous system pathologies (e.g., neurodegenerative/demyelinating diseases and brain tumours) develop neuroinflammation, a beneficial process during pathological events, aimed at removing damaged cells, toxic agents, and/or pathogens. Unfortunately, excessive inflammation frequently occurs during nervous system disorders, becoming a detrimental event capable of enhancing [...] Read more.
All nervous system pathologies (e.g., neurodegenerative/demyelinating diseases and brain tumours) develop neuroinflammation, a beneficial process during pathological events, aimed at removing damaged cells, toxic agents, and/or pathogens. Unfortunately, excessive inflammation frequently occurs during nervous system disorders, becoming a detrimental event capable of enhancing neurons and myelinating glial cell impairment, rather than improving their survival and activity. Consequently, targeting the neuroinflammation could be relevant for reducing brain injury and rescuing neuronal and glial cell functions. Several studies have highlighted the role of acetylcholine and its receptors in the regulation of central and peripheral inflammation. In particular, α7 nicotinic receptor has been described as one of the main regulators of the “brain cholinergic anti-inflammatory pathway”. Its expression in astrocytes and microglial cells and the ability to modulate anti-inflammatory cytokines make this receptor a new interesting therapeutic target for neuroinflammation regulation. In this review, we summarize the distribution and physiological functions of the α7 nicotinic receptor in glial cells (astrocytes and microglia) and its role in the modulation of neuroinflammation. Moreover, we explore how its altered expression and function contribute to the development of different neurological pathologies and exacerbate neuroinflammatory processes. Full article
(This article belongs to the Special Issue Cholinergic Control of Inflammation)
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