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Special Issue "Choroid Plexus: Novel Functions for an Old Structure 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Dr. Cecília R. Santos
E-Mail Website
Guest Editor
CICS-UBI - Health Sciences Research Centre , University of Beira Interior , Covilhã , Portugal
Interests: Neurodegeneration; choroid plexus
Special Issues and Collections in MDPI journals
Dr. Telma Quintela
E-Mail Website
Guest Editor
CICS‐UBI—Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Special Issues and Collections in MDPI journals
Dr. Isabel Goncalves
E-Mail
Guest Editor
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Interests: choroid plexus; brain barriers; chemical surveillance; taste and olfactory signaling; sex hormones
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Our first volume of the Special Issue "Choroid Plexus: Novel Functions for an Old Structure", clearly demonstrated the interest in the roles of the choroid plexus-cerebrospinal fluid system.

The first volume, highlighted the importance of the choroid plexus as a key player in the maintenance of the microenvironment of the central nervous system under both normal and pathological conditions.

We expect that the second volume of the Special Issue on "Choroid Plexus: Novel Functions for an Old Structure", continues to further increase and strengthen the knowledge of new choroid plexus functions in the pathophysiology of the central nervous system.

Dr. Cecília R. Santos
Dr. Telma Quintela
Dr. Isabel Goncalves
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Choroid plexus
  • Blood–cerebrospinal fluid barrier
  • Cerebrospinal fluid
  • Circadian clock

Published Papers (1 paper)

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Research

Open AccessArticle
Multiple Na,K-ATPase Subunits Colocalize in the Brush Border of Mouse Choroid Plexus Epithelial Cells
Int. J. Mol. Sci. 2021, 22(4), 1569; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22041569 - 04 Feb 2021
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Abstract
(1) Background: The unusual accumulation of Na,K-ATPase complexes in the brush border membrane of choroid plexus epithelial cells have intrigued researchers for decades. However, the full range of the expressed Na,K-ATPase subunits and their relation to the microvillus cytoskeleton remains unknown. (2) Methods: [...] Read more.
(1) Background: The unusual accumulation of Na,K-ATPase complexes in the brush border membrane of choroid plexus epithelial cells have intrigued researchers for decades. However, the full range of the expressed Na,K-ATPase subunits and their relation to the microvillus cytoskeleton remains unknown. (2) Methods: RT-PCR analysis, co-immunoprecipitation, native PAGE, mass spectrometry, and differential centrifugation were combined with high-resolution immunofluorescence histochemistry, proximity ligase assays, and stimulated emission depletion (STED) microscopy on mouse choroid plexus cells or tissues in order to resolve these issues. (3) Results: The choroid plexus epithelium expresses Na,K-ATPase subunits α1, α2, β1, β2, β3, and phospholemman. The α1, α2, β1, and β2, subunits are all localized to the brush border membrane, where they appear to form a complex. The ATPase complexes may stabilize in the brush border membrane via anchoring to microvillar actin indirectly through ankyrin-3 or directly via other co-precipitated proteins. Aquaporin 1 (AQP1) may form part of the proposed multi-protein complexes in contrast to another membrane protein, the Na-K-2Cl cotransporter 1 (NKCC1). NKCC1 expression seems necessary for full brush border membrane accumulation of the Na,K-ATPase in the choroid plexus. (4) Conclusion: A multitude of Na,K-ATPase subunits form molecular complexes in the choroid plexus brush border, which may bind to the cytoskeleton by various alternative actin binding proteins. Full article
(This article belongs to the Special Issue Choroid Plexus: Novel Functions for an Old Structure 2.0)
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