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Molecular Research on Chronic Fatigue Syndrome (CFS)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 3502

Special Issue Editors

1. Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daejeon 35235, Republic of Korea
2. Institute of Bioscience & Integrative Medicine, Daejeon University, Daejeon 35235, Republic of Korea
3. Department of Korean Medicine, Korean Medical College of Daejeon University, Daejeon 34520, Republic of Korea
Interests: tumor metastasis; chronic fatigue syndrome; liver disorders
Special Issues, Collections and Topics in MDPI journals
1. Institiute of Bioscience & Integrative Medicine, Daejeon Oriental Hospital of Daejeon University, Daejeon, Korea
2. Research Center for CFS/ME in Daejeon University,Daejeon, Daejeon, Korea
Interests: Chronic fatigue syndrome; Behavial and Emotional Disorders; Neuro-inflammation

Special Issue Information

Dear Colleagues,

Chronic fatigue syndrome (CFS) has been emerging as a significant health issue worldwide. CFS is a debilitating disease characterized by chronic fatigue > 6 months and post exertion malaise (PEM), unrefreshing sleep, cognitive impairment, and/or high susceptibility to pain. This illness impairs health-related quality of life seriously, thus approximately half of CFS patients are unemployed. The etiology of CFS however is still uncertain, and no established pathophysiology, objective diagnosis and therapeutics exist yet.

To date, many findings have proposed several biological etiologies of CFS, such as viral infection, autoimmune dysregulation, abnormal hypothalamic–pituitary–adrenal (HPA) axis response, immune impairment related to abnormal cytokine production including TGF-β. Most recently, microglial activation and neuro-inflammation are observed in the brains of CFS patients. In addition, there were promising strategies for objective diagnosis tools likely cardiopulmonary exercise tests as well as positive outcomes in therapeutic developments including cognitive behavioral therapy and some remedies.   

This Special Issue focuses on molecular mechanisms improving our understanding on CFS-related issues: potential etiology, pathophysiology, diagnostic tool and therapeutics. This Issue includes original articles, but other types of manuscripts are also welcomed.

Prof. Dr. Chang Gue Son
Prof. Dr. Jin Seok Lee
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • Chronic fatigue syndrome
  • Myalgic encephalomyelitis
  • Unexplained chronic fatigue
  • Post exertion malaise
  • Unrefreshing sleep
  • Cognitive impairment
  • HPA axis
  • Neuro-inflammation
  • Microglial activation
  • TGF-β

Published Papers (1 paper)

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Research

23 pages, 37683 KiB  
Article
Improvement Effects of Myelophil on Symptoms of Chronic Fatigue Syndrome in a Reserpine-Induced Mouse Model
by Ji-Hye Song, Seul-Ki Won, Geun-Hyang Eom, Da-Som Lee, Byung-Jin Park, Jin-Seok Lee, Chang-Gue Son and Ji-Yeun Park
Int. J. Mol. Sci. 2021, 22(19), 10199; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910199 - 22 Sep 2021
Cited by 4 | Viewed by 2765
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is associated with various symptoms, such as depression, pain, and fatigue. To date, the pathological mechanisms and therapeutics remain uncertain. The purpose of this study was to investigate the effect of myelophil (MYP), composed of Astragali Radix and [...] Read more.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is associated with various symptoms, such as depression, pain, and fatigue. To date, the pathological mechanisms and therapeutics remain uncertain. The purpose of this study was to investigate the effect of myelophil (MYP), composed of Astragali Radix and Salviaemiltiorrhizae Radix, on depression, pain, and fatigue behaviors and its underlying mechanisms. Reserpine (2 mg/kg for 10 days, intraperitoneally) induced depression, pain, and fatigue behaviors in mice. MYP treatment (100 mg/kg for 10 days, intragastrically) significantly improved depression behaviors, mechanical and thermal hypersensitivity, and fatigue behavior. MYP treatment regulated the expression of c-Fos, 5-HT1A/B receptors, and transforming growth factor β (TGF-β) in the brain, especially in the motor cortex, hippocampus, and nucleus of the solitary tract. MYP treatment decreased ionized calcium binding adapter molecule 1 (Iba1) expression in the hippocampus and increased tyrosine hydroxylase (TH) expression and the levels of dopamine and serotonin in the striatum. MYP treatment altered inflammatory and anti-oxidative-related mRNA expression in the spleen and liver. In conclusion, MYP was effective in recovering major symptoms of ME/CFS and was associated with the regulation of dopaminergic and serotonergic pathways and TGF-β expression in the brain, as well as anti-inflammatory and anti-oxidant mechanisms in internal organs. Full article
(This article belongs to the Special Issue Molecular Research on Chronic Fatigue Syndrome (CFS))
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