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Circadian Clock and Reproduction
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Circadian Clock and Reproduction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 11057

Special Issue Editor

Dr. Masanori Ono

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan
Interests: reproduction; circadian clock; feeding; dysmenorrhea; adolescent; clock gene; dieting; obstetric and gynecological diseases; stem cells; tissue stem cells

Special Issue Information

Dear Colleagues,

In an environment wherein exposure to chronodisruptors, such as night lighting, shift work, midnight meals, dieting, and transmeridian travel, has come to be the norm, the effects of these factors on women with menstrual abnormalities, infertile couples, and pregnant women warrant closer attention. The mammalian circadian clock integrates the hypothalamus and suprachiasmatic nucleus (SCN) and is regulated by environmental light/dark conditions (day and night). Alternatively, it is known that a few physiological rhythms, as a result of the timing of feeding, diverge from the time manipulation of the SCN, and are studied as independent peripheral biological circadian molecular clock mechanisms.

The coordination between ovulation, fertilization, the peristaltic action of the fallopian tube, uterine contraction, and implantation is important. It has been reported that the circadian clock controls the cell division of cells, including stem cells in an appropriate timing. The rhythm of the clock genes play an important role in each timing. Optimal fertility also relies upon the exact timing of the surge of GnRH and LH secretion. Therefore, elucidation of the factors that modify circadian rhythms, especially in the reproductive organs and the hypothalamic–pituitary–gonadal axis (HPG axis), will provide insights into how to treat reproductive dysfunction. The main feature of this Special Issue is to provide an open source collection of significant work in the field of reproduction related to the circadian clock.

Article formats that will be considered for this Special Issue include:

  • Original research manuscripts;
  • Reviews.

Dr. Masanori Ono
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproduction
  • circadian clock
  • feeding
  • dysmenorrhea
  • adolescent
  • clock gene
  • dieting
  • obstetric and gynecological diseases
  • stem cells
  • tissue stem cells

Published Papers (2 papers)

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Review

13 pages, 1011 KiB  
Review
The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship
by Masanori Ono, Hitoshi Ando, Takiko Daikoku, Tomoko Fujiwara, Michihiro Mieda, Yasunari Mizumoto, Takashi Iizuka, Kyosuke Kagami, Takashi Hosono, Satoshi Nomura, Natsumi Toyoda, Naomi Sekizuka-Kagami, Yoshiko Maida, Naoaki Kuji, Hirotaka Nishi and Hiroshi Fujiwara
Int. J. Mol. Sci. 2023, 24(2), 1545; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24021545 - 12 Jan 2023
Cited by 7 | Viewed by 2630
Abstract
The circadian rhythm, which is necessary for reproduction, is controlled by clock genes. In the mouse uterus, the oscillation of the circadian clock gene has been observed. The transcription of the core clock gene period (Per) and cryptochrome (Cry) [...] Read more.
The circadian rhythm, which is necessary for reproduction, is controlled by clock genes. In the mouse uterus, the oscillation of the circadian clock gene has been observed. The transcription of the core clock gene period (Per) and cryptochrome (Cry) is activated by the heterodimer of the transcription factor circadian locomotor output cycles kaput (Clock) and brain and muscle Arnt-like protein-1 (Bmal1). By binding to E-box sequences in the promoters of Per1/2 and Cry1/2 genes, the CLOCK-BMAL1 heterodimer promotes the transcription of these genes. Per1/2 and Cry1/2 form a complex with the Clock/Bmal1 heterodimer and inactivate its transcriptional activities. Endometrial BMAL1 expression levels are lower in human recurrent-miscarriage sufferers. Additionally, it was shown that the presence of BMAL1-depleted decidual cells prevents trophoblast invasion, highlighting the importance of the endometrial clock throughout pregnancy. It is widely known that hormone synthesis is disturbed and sterility develops in Bmal1-deficient mice. Recently, we discovered that animals with uterus-specific Bmal1 loss also had poor placental development, and these mice also had intrauterine fetal death. Furthermore, it was shown that time-restricted feeding controlled the uterine clock’s circadian rhythm. The uterine clock system may be a possibility for pregnancy complications, according to these results. We summarize the most recent research on the close connection between the circadian clock and reproduction in this review. Full article
(This article belongs to the Special Issue Circadian Clock and Reproduction)
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32 pages, 1266 KiB  
Review
Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents
by Alexandra M. Yaw, Autumn K. McLane-Svoboda and Hanne M. Hoffmann
Int. J. Mol. Sci. 2021, 22(1), 324; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010324 - 30 Dec 2020
Cited by 17 | Viewed by 7973
Abstract
Shiftwork, including work that takes place at night (nightshift) and/or rotates between day and nightshifts, plays an important role in our society, but is associated with decreased health, including reproductive dysfunction. One key factor in shiftwork, exposure to light at night, has been [...] Read more.
Shiftwork, including work that takes place at night (nightshift) and/or rotates between day and nightshifts, plays an important role in our society, but is associated with decreased health, including reproductive dysfunction. One key factor in shiftwork, exposure to light at night, has been identified as a likely contributor to the underlying health risks associated with shiftwork. Light at night disrupts the behavioral and molecular circadian timekeeping system, which is important for coordinated timing of physiological processes, causing mistimed hormone release and impaired physiological functions. This review focuses on the impact of shiftwork on reproductive function and pregnancy in women and laboratory rodents and potential underlying molecular mechanisms. We summarize the negative impact of shiftwork on female fertility and compare these findings to studies in rodent models of light shifts. Light-shift rodent models recapitulate several aspects of reproductive dysfunction found in shift workers, and their comparison with human studies can enable a deeper understanding of physiological and hormonal responses to light shifts and the underlying molecular mechanisms that may lead to reproductive disruption in human shift workers. The contributions of human and rodent studies are essential to identify the origins of impaired fertility in women employed in shiftwork. Full article
(This article belongs to the Special Issue Circadian Clock and Reproduction)
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