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Special Issue "Circadian Regulation of Oncogenes and Tumor Suppressor Genes"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 10 February 2022.

Special Issue Editor

Dr. Marina Maria Bellet
E-Mail Website1 Website2 Website3
Guest Editor
Dipartimento di Medicina Sperimentale, Università degli Studi di Perugia, 06132 Perugia, Italy
Interests: circadian rhythm; clock genes; chronotherapy; epigenetics; lung infections; immunology; cystic fibrosis

Special Issue Information

Dear Colleagues,

The circadian clock driven by the daily light–dark and temperature cycles of the environment regulates fundamental physiological processes and perturbations of these sophisticated mechanisms may result in pathological conditions, including tumor development. A circadian regulation has been proposed for key aspects of cancer cell biology, including cell cycle, genotoxic stress response and metabolism. In particular, several intersections have been identified between clock components and proteins involved in cancerogenesis, including oncogenes and tumor suppressors. A tumor suppressor function has been hypothesized for the circadian proteins themselves, although several studies have suggested that circadian factors might have context-dependent pro-tumorigenic and anti-tumorigenic roles. In addition, the tumor itself might regulate the circadian homeostasis, thus suggesting a reciprocal regulation between tumorigenesis and circadian rhythms. Here, we propose to collect studies focusing on how the circadian clock interfaces with many oncogenes and tumor suppressors. We particularly welcome manuscripts on the following subjects:

  • Regulation of oncogenes and tumor suppressors by the circadian clock;
  • Tissue-specific circadian control of tumorigenesis;
  • Role of clock genes as putative oncogenes/tumor suppressor genes;
  • Deregulation of circadian rhythms by oncogenes or tumor suppressors.

Dr. Marina Maria Bellet
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • circadian rhythm
  • clock genes
  • oncogenes
  • tumor suppressors
  • tumorigenesis

Published Papers

This special issue is now open for submission.
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