Special Issue "Circadian Regulation of Oncogenes and Tumor Suppressor Genes"
Deadline for manuscript submissions: 10 February 2022.
The circadian clock driven by the daily light–dark and temperature cycles of the environment regulates fundamental physiological processes and perturbations of these sophisticated mechanisms may result in pathological conditions, including tumor development. A circadian regulation has been proposed for key aspects of cancer cell biology, including cell cycle, genotoxic stress response and metabolism. In particular, several intersections have been identified between clock components and proteins involved in cancerogenesis, including oncogenes and tumor suppressors. A tumor suppressor function has been hypothesized for the circadian proteins themselves, although several studies have suggested that circadian factors might have context-dependent pro-tumorigenic and anti-tumorigenic roles. In addition, the tumor itself might regulate the circadian homeostasis, thus suggesting a reciprocal regulation between tumorigenesis and circadian rhythms. Here, we propose to collect studies focusing on how the circadian clock interfaces with many oncogenes and tumor suppressors. We particularly welcome manuscripts on the following subjects:
- Regulation of oncogenes and tumor suppressors by the circadian clock;
- Tissue-specific circadian control of tumorigenesis;
- Role of clock genes as putative oncogenes/tumor suppressor genes;
- Deregulation of circadian rhythms by oncogenes or tumor suppressors.
Dr. Marina Maria Bellet
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- circadian rhythm
- clock genes
- tumor suppressors