Special Issue "CoA in Health and Disease"
Deadline for manuscript submissions: 30 April 2021.
Interests: physiology; endocrinology; metabolism; lipids; lipogenesis; lipolysis; stearoyl-CoA desaturase; angiogenesis; cardiovascular system; mitochondria; obesity; type 2 diabetes; transcription factors
CoA and its thioester derivatives are crucial components of numerous biosynthetic and degradative pathways of cellular metabolism (including synthesis and oxidation of fatty acids, the Krebs cycle, ketogenesis, biosynthesis of cholesterol and acetylcholine, degradation of amino acids), post-translational modifications of proteins, and the regulation of gene expression. Consequently, it is not surprising that abnormal biosynthesis of CoA/CoA derivatives are associated with numerous pathologies, including diabetes, neurodegeneration, Reye’s syndrome, vitamin B12 deficiency, cardiac hypertrophy, and cancer. This Special Issue of IJMS will showcase selected novel research articles covering the multiple roles of CoA and its derivatives on extracellular and intracellular signaling functions in physiology and pathology. Topics of interest to this Special Issue include but are not limited to:
• CoA synthesis and degradation;
• CoA transport and mitochondria;
• Extracellular functions of CoA/CoA thioesters;
• CoA/CoA thioesters as intracellular signaling molecules;
• Physiological and pathological changes in cellular CoA concentrations;
• Interconversion between CoA and its thioester derivatives in health and disease;
• The role of nutrients, hormones, and other factors in the regulation of CoA levels in cells;
• Acyl-CoA metabolism;
• Association of CoA/acyl-CoA with fatty acid metabolism.
In addition, critical reviews of the status and perspectives regarding the role of CoA in pathophysiology are welcomed.
Dr. Pawel Dobrzyn
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- energy production
- impaired metabolism
- acyl-CoA synthesis and function
- CoA analogues
- oxidative stress
- hereditary diseases
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The role of the stearoyl CoA desaturase 1
Title: The stearoyl CoA desaturase as an anti-inflammatory therapeutic target
Title: Metabolic compartmentation of Acetyl-CoA: implications for metabolic tracer studies
Title: Clinicopathological aspects of acyl-CoA related diseases in muscle
Title: Mitochondrial CoA and dPCoA transport system
Title: The pathophysiological role of CoA concentrations