Dear Colleagues,

The treatment of liver metastases from colorectal cancer has dramatically evolved during the last two decades: Parallel to the evolution of various multidrug systemic chemotherapy protocols, surgery has become a standard treatment with curative potential, and resectability has become a central treatment aim. Consequently, staged surgical concepts have been established and multimodality regimens with the aim of increasing resectability on the one hand and decreasing postoperative recurrence rates on the other are widely used in current practice.

Moreover, local ablative treatments and minimal-invasive surgery extend current treatment options with the aim of reducing morbidity in a multimodality treatment.

In addition to research on more efficient and better treatment regimen, the optimal treatment choice for an individual patient is currently a major challenge. Particularly in this setting, molecular tumor characteristics are gaining increasing importance in addition to established clinical scoring systems and histological parameters.

This open-access Special Issue is dedicated to reflect the most recent results on molecular selection criteria for chemotherapy as well as surgery and local ablative treatments in the treatment of liver metastases from colorectal cancer.

Therefore, topics of this Special Issue include but are not limited to:

• Molecular tumor pathology, angiogenesis, and signaling pathways;
• Tumor microenvironment;
• Cancer biomarkers: treatment response, prognosis;
• Cancer therapy: target discovery, drug design, resistance, targeted therapy, personalized medicine;
• Translational cancer research;
• High-throughput technologies: genomics, epigenomics, proteomics, metabolomics, microarray, next generation sequencing, and other omics technologies;
• Genomic and proteomic databases and applications.

Dr. Stefan Heinrich
Guest Editor

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• Liver metastases
• Colorectal cancer
• Individualized treatment concepts
• Targeted therapy
• Liver surgery
• Chemotherapy
• Patient selection