Special Issue "Development of Active Compounds to Combat Antibiotic Resistant Microorganisms"
Deadline for manuscript submissions: 31 July 2021.
Interests: plant cell tissue, synergistic combination of drugs; biologically active compounds; transformation; phytopharmaceuticals; green synthesis of nanoparticles; drug resistance of bacteria
Interests: plant secondary metabolites; bacterial pathogens; antimicrobials; antibiotic resistance; nanotechnology; drug synergy; drug antagonism; Caenorhabditis elegans
While the discovery of antibiotics in the mid-20th century transformed human health, several antibiotic-resistant bacterial strains were identified in the decades that followed. Currently, despite the broad spectrum of antimicrobial compounds, bacterial infections are among the leading causes of death. Moreover, infections resulting from multidrug-resistant bacteria (MDR) strains are an increasing problem in modern medicine, with the ESCAPE group comprising the most threatening bacteria species. Due to bacterial resistance and a limited possibility of a new antibiotic breakthrough, we are inevitably faced with further development of new therapeutic methods to combat human bacterial pathogens.
The mechanisms of bacterial resistance are diverse and include such defense mechanisms as drug enzymatic degradation, removal of compound with the use of pumps (active transport), modifications of drug-target sites of action, or creation of an alternative metabolic pathway. The extensive defense mechanisms presented by bacteria demand a combined effort, encompassing various fields of research, from plant sciences, nanotechnology, chemistry, to computer modeling.
To address the Special Issue of treating bacterial infections caused by MDR bacteria, we are searching for new antibiotics, natural-occurring antibacterial compounds, e.g., plant secondary metabolites or peptides, synthetic substances, e.g., metal nanoparticles, and combining antibacterial substances and/or therapies aimed at obtaining a synergistic effect to prevent bacterial resistance. Reduction in effective doses and diminished toxicity towards human cells, as well as the final multi-target antimicrobial effect, are significant advantages of synergy.
Dr. Aleksandra Królicka
Dr. Marta Krychowiak-Maśnicka
Manuscript Submission Information
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- metal nanoparticles
- in vitro and in vivo studies
- plant secondary metabolites
- synthetic peptides
- new antimicrobials
- antimicrobial activity
- non-toxic towards eukaryotic cells
- computer modeling
- artificial intelligence algorithms