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Special Issue "DNA Damage and Repair in Biology and Medicine"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Guillermo T. Sáez
E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine and Odontology-INCLIVA, Service of Clinical Analysis, Dr. Peset University Hospital -FISABIO, University of Valencia, Avda. Blasco Ibañez 15, 46010 Valencia, Spain
Interests: oxidative stress-induced DNA damage and its repair in cardiometabolic and cancer diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Celia Banuls
Guest Editor
Endocrinology Service, Dr. Peset University Hospital-FISABIO External Consulting Building, C / Juan de Garay 21 46017 Valencia, Spain

Special Issue Information

Dear colleagues,

Despite its strategic location and apparent protection, the integrity of the genetic material is the result of a continuous and delicate balance between the mechanisms that induce its injury and those in charge of its repair, whose effectiveness is vital for the normal functioning of the cells and the perpetuity in the transmission of the genetic message in a faithful way. The modalities and mechanisms of DNA damage are very varied, including different forms of structural modification and functional alteration. Together with exogenous factors such as those induced by chemical agents and ionizing radiation, cells must cope with a rate of genetic damage of 103 to 106 impacts per cell and day to which normal aerobic metabolism contributes, with the production of reactive species of oxygen (ROS) (3-5% of breathed oxygen) and the consequent alteration of the redox balance which may have profound effects on the regulation of cell signaling pathways. In DNA molecule structure, many of these lesions can stop replication and alter or inhibit gene transcription. Other lesions, if not repaired before replication takes place, may induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. Genomic instability is an essential step in the development of age associated comorbidities, such as cardiometabolic disorders, tissue failure and tumor processes. Higher animals, microorganisms, and plants are susceptible to this potential hazard. Fortunately, evolution has allowed the development of a plethora of diverse, specific and efficient DNA repair systems, under the control of multiple molecules and transcriptional factors. The TP53 protein, also known as the guardian of the genome, together with other onco and tumor suppressor proteins are representative examples.
It is vitally important to know in detail both the mechanisms that lead to genetic instability and those that prevent and repair it. In this sense, the Special Issue "DNA damage and repair in biology in medicine" tries to bring together contributions by research groups that bring new light on their molecular mechanisms and future perspectives on their translational applications.

Prof. Dr. Guillermo T. Sáez
Dr. Celia Banuls
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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