Special Issue "DNA Damage Response, an Update"
Deadline for manuscript submissions: 31 August 2021.
Interests: molecular biology; post translational modifications; phosphorylation; tyrosine kinases; cell signaling pathways
DNA damage response (DDR) represents the way cells react to preserve genome integrity. DNA breaks can arise either spontaneously, during replication, or in response to exogenous compounds. Biochemical characterization of signaling events underlying the DDR has allowed the design and the development of specific inhibitors. Nonetheless, their potential use in monotherapy strategies or in combination with radiotherapy or chemotherapy against cancer cells has not given the expected results. This may be due to the fact that DDR is controlled in a redundant way through intricate and complex mechanisms. These mechanisms involve either post-translational modifications on chromatin, expression of small regulatory RNAs, or changes in chromatin architecture. In this topic, we invite the submission of original research papers and review articles that cover any aspect of DDR. Special emphasis will be given to the emerging crosstalk between DDR and other cellular signaling paths, occurring either in physiological or pathological conditions.
Dr. Stefania Gonfloni
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- DNA damage
- Cellular differentiation
- Metabolic disease
- Mitochondrial dysfunction