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Special Issue "DNA Damage Response, an Update"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Stefania Gonfloni
E-Mail Website
Guest Editor
Dipartimento di Biologia,University of Rome Tor Vergata | UNIROMA2
Interests: molecular biology; post translational modifications; phosphorylation; tyrosine kinases; cell signaling pathways

Special Issue Information

Dear Colleagues,

DNA damage response (DDR) represents the way cells react to preserve genome integrity. DNA breaks can arise either spontaneously, during replication, or in response to exogenous compounds. Biochemical characterization of signaling events underlying the DDR has allowed the design and the development of specific inhibitors. Nonetheless, their potential use in monotherapy strategies or in combination with radiotherapy or chemotherapy against cancer cells has not given the expected results. This may be due to the fact that DDR is controlled in a redundant way through intricate and complex mechanisms. These mechanisms involve either post-translational modifications on chromatin, expression of small regulatory RNAs, or changes in chromatin architecture. In this topic, we invite the submission of original research papers and review articles that cover any aspect of DDR. Special emphasis will be given to the emerging crosstalk between DDR and other cellular signaling paths, occurring either in physiological or pathological conditions.

Dr. Stefania Gonfloni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA damage
  • Cellular differentiation
  • Autophagy
  • Metabolic disease
  • Mitochondrial dysfunction

Published Papers

This special issue is now open for submission.
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