Special Issue "Molecular Mechanisms of Dementia—Application to Its Biomarkers"
Deadline for manuscript submissions: 31 October 2021.
Interests: plasma biomarkers; neuron-derived extracellular vesicles; liquid biopsy
Guest Editor Assistant
Recently, the molecular mechanisms of dementia are gradually becoming clearer. Among them, for Alzheimer's disease (AD), the "amyloid cascade hypothesis" has been proposed and has been supported by many researchers. Based on this hypothesis, diagnostic biomarkers for AD have been established. The main ones are amyloid PET and the measurement of Aβ40, Aβ42, and phosphorylated tau in cerebrospinal fluid (CSF). However, amyloid PET is expensive, and CSF collection has invasive problems, leaving doubts about its clinical applicability. The amyloid hypothesis is also leading AD-modifying agents such as amyloid vaccine therapy to clinical use. Because it has been pointed out that such interventions cannot be expected to be effective unless they are performed very early in the disease, early diagnosis is becoming more important. Against this background, the establishment of blood biomarkers for AD that can be easily measured is an urgent issue.
On the other hand, clinical trials of these AD-modifying agents have been struggling, and questions have been raised as to whether the amyloid hypothesis is correct. Therefore, a paradigm shift may be necessary for the hypothesis of the molecular mechanisms of dementia.
In this Special Issue, we would like to introduce the molecular mechanisms of dementia, including the "amyloid cascade hypothesis," and introduce their application to biomarkers of dementia.
Prof. Takashi Kudo
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- phosphorylated tau
- neurofilament L
- extracellular vesicles