Special Issue "Skeletal Muscle Denervation"
Deadline for manuscript submissions: 30 June 2021.
Interests: Skeletal muscle; tendon; aging; denervation; obesity; myokines
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Skeletal muscle is a second largest organ of the human body. In addition to its essential role for locomotion, maintaining posture, respiration (diaphragm), and phonation (laryngeal muscles), skeletal muscle plays a critical role in whole-body metabolism. Skeletal muscle is a major organ responsible for insulin-stimulated glucose utilization in humans. Myokine secreted by skeletal muscle can affect the metabolism of distant organs, including the liver and adipose tissue.
Normal skeletal muscle development, structural organization, and function require innervation. Loss of muscle innervation during development results in a defective musculoskeletal unit (muscle–tendon–bone) structure. Loss of muscle innervation in a mature muscle leads to the loss of contractile proteins and to muscle atrophy.
Skeletal muscle denervation has been the focus of many studies that have uncovered multiple complex and often intertwined mechanisms. Nevertheless, many aspects of muscle denervation and especially the approaches to the prevention and treatment of denervation-induced muscle atrophy are still not completely understood. A better understanding of the mechanisms regulating skeletal muscle denervation will enable the prevention and treatment of the denervation-induced muscle dysfunction. In this Special Issue titled “Skeletal Muscle Denervation”, we would like to highlight the latest advances in this research topic.
We invite authors to submit original research and review articles revealing the molecular mechanisms of skeletal muscle denervation, including, but not limited to, the following topics:
- Denervation-induced developmental skeletal muscle abnormalities;
- Denervation-induced skeletal muscle atrophy;
- Aging-related skeletal muscle denervation;
- Diseases associated with skeletal muscle denervation;
- Signaling involved in skeletal muscle denervation;
- Denervation-induced changes in gene expression in skeletal muscle;
- Oxidative and endoplasmic reticulum stress activated in response to skeletal muscle denervation;
- Denervation-related changes in myokine expression/secretion in skeletal muscle.
Dr. Tatiana Kostrominova
Dr. Susan V. Brooks
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.