Special Issue "The Pathogenesis and Therapeutic Strategies for Understanding and Treating Diabetic Neuropathy of the Retina"
Deadline for manuscript submissions: 31 August 2021.
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Chiba, Japan
Interests: diabetic retinopathy; neuronal cell death; neurovascular units; axonal degeneration; glial changes; vascular abnormalities; neuroprotection; regeneration; optic coherence tomography; visual function
There is growing evidence that not only vascular abnormalities but also neuronal abnormalities, including retinal neuronal cell death, are associated with the pathogenesis of diabetic retinopathy. Neuronal cell death is an irreversible change and directly leads to vision loss in diabetic patients. In addition, numerous studies have demonstrated that retinal ganglion cell axons and dendrites are degenerated in the early stage of diabetes. The ultimate purpose of the therapies for patients with diabetic retinopathy is to protect their visual function by neuroprotection, axonal protection, and regeneration. However, the precise pathogenesis of diabetic neuropathy in the retina are still unclear. Diabetic retinopathy is a chronic retinal disease, and it is difficult to determine the pathogenesis of the onset and the progression of neuronal degeneration. Thus, some clues to determine the pathogenesis of the development and the progression of diabetic neuropathy in the retina must be obtained from other acute injury models such as ischemia and physical injury models. Therefore, in this Special Issue, we welcome articles from wide areas of neuroscience that are able to provide clues to determine the pathogenesis of diabetic neuropathy in the retina and to apply therapeutic strategies for the neuroprotection and regeneration of the neurons damaged by diabetic retinopathy.
Prof. Dr. Toshiyuki Oshitari
Manuscript Submission Information
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- diabetic retinopathy
- neuronal cell death
- neurovascular units
- axonal degeneration
- glial changes
- vascular abnormalities
- optic coherence tomography
- visual function