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Special Issue "Molecular Mechanisms of Endocrine-Disrupting Chemicals (EDC) Action in the Pathogenesis of Human Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Prof. Dr. Dariusz Szukiewicz
E-Mail Website
Guest Editor
Department of Biophysics, Physiology and Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chalubinskiego 5 (4th Floor), 02-004 Warsaw, Poland
Interests: inflammation; cytokine network; human placenta; stem cells in reproductive tissues; pathophysiology of diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endocrine-disrupting chemicals are exogenous agents that interfere with the synthesis, secretion, transport, metabolism, binding action, or elimination of natural blood-borne hormones that are present in the body and are responsible for homeostasis, reproduction, and the developmental process. Many chemicals, both natural (e.g., phytoestrogens, some metals) and man-made (e.g., bisphenol A–BPA from plastics, dichlorodiphenyltrichloroethane–DDT from pesticides, and diethylstilbestrol–DES from pharmaceutical agents), may mimic or interfere with the body’s endocrine system. EDC-related adverse human health outcomes include abnormal function of the reproductive system, endometriosis, early puberty, certain cancers, altered nervous system function, immune disorders, growth disorders, respiratory and cardiovascular problems, and metabolic issues (e.g., diabetes, obesity). The broad spectrum of EDC activities includes, but is not limited to, estrogenic, antiandrogenic, thyroid, peroxisome proliferator-activated receptor γ and retinoid signaling pathways. These are highly conserved in the evolution pathways and can be modeled in laboratory in vitro and in vivo models. The related research includes elaborating on better models and tools for understanding the mechanisms of EDC action, precise methods of EDC identification, understanding the relationship  between exposure to EDC and health efects, developing strategies to reduce or prevent exposures.

This Special Issue is dedicated to all aspects of EDC impact on human health and, in particular, EDC contribution to the pathogenesis of diseases in the context of new therapeutic strategies. When considering your submission, please keep in mind that IJMS is a journal of molecular science. However, submissions of clinical studies with biomolecular experiments or pathological research with case sample data are welcomed.

Prof. Dr. Dariusz Szukiewicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • endocrine-disrupting chemicals
  • environmental pollution
  • environmental health threats
  • endocrine disruption
  • abnormal estrogen signaling
  • metabolic imbalances
  • reproductive health
  • carcinogenesis

Published Papers

This special issue is now open for submission.
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