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Special Issue "ERAD and Ubiquitination 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Jun Imai
E-Mail Website
Guest Editor
Laboratory of Physiological Chemistry, Faculty of Pharmacy, Department of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki-shi, Gunmma 370-0033, Japan
Interests: cross presentation; dendritic cell; the ubiquitin proteasome system; antigen presentation
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Last year, we launched the Special Issue “ERAD and Ubiquitination”, in which we published two research articles and four reviews. There has since been a constant influx of exciting findings in the literature, indicating this area of research has become a hot topic. Therefore, we wish to renew this Special Issue for 2021. ERAD (endoplasmic reticulum-associated degradation) has been identified as a cellular pathway of the protein quality control system in the ER, in which proteins in the ER specifically recognized as being misfolded or unassembled undergo retrograde transport out of the ER lumen and into the cytosol, where they are ubiquitinated and then degraded by proteasomes. Ubiquitination in ERAD plays a central role in the degradation of ERAD substrates by proteasomes but also functions as a recognition signal for retro-translocation and adjustment signals between ERAD-related molecular machinery. Disorders of ERAD-related ubiquitination result from activation of the UPR (unfolded protein response), and recent investigations have revealed that the UPR plays substantial roles in tumor progression, immunity, development, and aging. In this Special Issue of IJMS, we will address the role of ubiquitination in ERAD. This Special Issue will highlight the expansion in our understanding of the numerous roles of ERAD-related ubiquitination in various processes ranging from cellular homeostasis to individual homeostasis and development.

Prof. Dr. Jun Imai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.




CUE domain;

ubiquitin chain conformation

Published Papers

This special issue is now open for submission.
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