Special Issue "ERK Signaling Pathway in Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 January 2019).
The ERK signaling pathway plays a central role in the control of various cellular processes, such as proliferation, survival, differentiation, and development, as well as apoptosis and stress response. Compartmentalization and dynamic localization of ERK signaling is an important regulatory mechanism of specific biological processes. Consistent with its critical role in key cellular functions, deviation in the normal activities of this pathway has been implicated in the development of many human diseases involving different organs. In particular, mutations hitting the ERK signaling are involved in autosomal-dominant syndromes known as RASopathies. The major complications of these disorders are congenital cardiac defects and development of hypertrophic cardiomyopathy. Furthermore, in the neuronal system ERK has been correlated to different pathological contexts, including stroke, autism and neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. In the nervous system, ERK pathway regulates various cellular activities including neuron apoptosis through induction of excitotoxicity, neuroinflammation and innate immunity. In addition, ERK has been deeply investigated as anti-cancer target molecule for its important role in tumorigenesis in particular in cancer cell proliferation, migration and invasion. Finally, ERK has been also associated to the development of side effects derived from anti-cancer therapies, such as cardiotoxicity due to chemotherapeutic treatments. Overall, these data suggest that a major comprehension of the pathological mechanisms regulated by the ERK pathway will allow the development of new functional therapies for a great range of diseases with a strong impact on public health.
In this Special Issue of the International Journal of Molecular Sciences the focus will be on the role of the ERK signaling pathway in various pathologies, such as cancer, developmental disorders and diseases affecting the cardiovascular and nervous system.
Prof. Tiziana Crepaldi
Manuscript Submission Information
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- ERK signaling pathway
- Developmental Disorders
- Cardiovascular system
- Nervous System