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Special Issue "Endoplasmic Reticulum Stress and Unfolded Protein Response 2021"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Prof. Ireneusz Majsterek
Guest Editor
Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lodz, Poland
Interests: UPR; ER stress; PERK; PERK inhibitors; apoptosis; neurodegeneration; cancer
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The endoplasmic reticulum (ER) plays a role in the maintenance of numerous aspects of cellular and organismal homeostasis by folding, modifying, and exporting nascent secretory and transmembrane proteins. Failure of the ER's adaptive capacity results in accumulation of unfolded or malfolded proteins in the ER lumen (ER stress). To avoid cellular damage, mammalian cells activate the specific signals from the ER to the cytosol or nucleus to enhance the capacity for protein folding, attenuate the synthesis of proteins, and degrade unfolded proteins. These signaling pathways are collectively known as the unfolded protein response (UPR). UPR was originally described as a system by which cells evade damage in response to acute ER perturbation. However, recent advances have revealed that UPR also regulates cell differentiation and maturation or basal cellular homeostasis. Further, ER stress has been reported to have relationships with neurodegenerative diseases, diabetes, metabolic syndromes, and cancer. Therefore, it has been attracting attention in terms of elucidating pathogenic mechanisms and developing therapeutics.

This Special Issue provides diverse aspects of ER stress and UPR in various physiological and pathological events. We invite authors to submit original research and review articles related to any research into ER stress and UPR signaling.

Prof. Ireneusz Majsterek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • ER stress
  • UPR signaling
  • Physiological ER stress
  • Protein folding
  • Unfolded proteins
  • ER stress sensors
  • ER-associated degradation
  • Protein quality control
  • ER stress-induced cell death
  • Protein misfolding disease

Published Papers

This special issue is now open for submission.
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