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Special Issue "Ejaculated and Testicular Spermatozoa: Molecular Biological Research of Morphology, Physiology and Spermatogenesis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 22 February 2022.

Special Issue Editors

Dr. Vladimir Isachenko
E-Mail Website
Guest Editor
Leader of Research Group for Reproductive Medicine, Medical Faculty, University of Cologne, Cologne, Germany
Interests: cancer; cells; cryopreservation; embryo; proliferation; reproductive; spermatozoa; oocyte; ovarian tissue
Dr. Marc Yeste
E-Mail Website1 Website2
Guest Editor
Biotechnology of Animal and Human Reproduction (TechnoSperm), Department of Biology, Institute of Food and Agricultural Technology, University of Girona, Pic de Peguera 15, 17003 Girona, Spain
Interests: cell biology; molecular biology; reproductive biology; cryobiology; sperm; oocyte; embryo; infertility; human reproduction; animal reproduction
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, “Ejaculated and Testicular Spermatozoa: Molecular Biological Research into Morphology, Physiology and Spermatogenesis”, will cover a selection of recent research and current review articles in the field. The cryopreservation of spermatozoa leads to sperm cell damage. Intracellular and extracellular ice-crystal formation and osmotic damage to cells can further deteriorate their viability. The production of reactive oxygen species leads to an increase in lipid peroxidation after the cryopreservation of spermatozoa, which is associated with a loss of sperm motility. Cryopreservation also leads to diminished antioxidant defense activity during cooling and (or) structural damage to the cytoskeleton and (or) antioxidant enzymes. It can also lead to chromatin damage, which is extremely important because chromatin abnormalities have repercussions on sperm quality and male fertility. Additionally, sperm DNA damage is strongly correlated with the mutagenic effects of cryopreservation. The viability of spermatozoa drops significantly after cryopreservation with respect to that of fresh sperm. The study of such cryo-changes using molecular biological methods will certainly help in the development of more efficient technologies for spermatozoon cryopreservation. It is also known that the cryo-biological properties of spermatozoa can change during the process of spermatogenesis. For example, a direct correlation is expected between the synthesis of proteins (natural cryoprotectants) and the cryo-properties of spermatozoa. Thus, this Special Issue of the journal is devoted not only to research directly related to the cryopreservation of cells, but also to the study of the characteristics of spermatogenesis, theoretically associated with the cryo-resistance of spermatozoa.

Dr. (SU) Vladimir Isachenko
Dr. Marc Yeste
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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