Special Issue "Ejaculated and Testicular Spermatozoa: Molecular Biological Research of Morphology, Physiology and Spermatogenesis"
Deadline for manuscript submissions: 22 February 2022.
Interests: cancer; cells; cryopreservation; embryo; proliferation; reproductive; spermatozoa; oocyte; ovarian tissue
Interests: cell biology; molecular biology; reproductive biology; cryobiology; sperm; oocyte; embryo; infertility; human reproduction; animal reproduction
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Cryopreservation of Gametes and Embryos
This Special Issue, “Ejaculated and Testicular Spermatozoa: Molecular Biological Research into Morphology, Physiology and Spermatogenesis”, will cover a selection of recent research and current review articles in the field. The cryopreservation of spermatozoa leads to sperm cell damage. Intracellular and extracellular ice-crystal formation and osmotic damage to cells can further deteriorate their viability. The production of reactive oxygen species leads to an increase in lipid peroxidation after the cryopreservation of spermatozoa, which is associated with a loss of sperm motility. Cryopreservation also leads to diminished antioxidant defense activity during cooling and (or) structural damage to the cytoskeleton and (or) antioxidant enzymes. It can also lead to chromatin damage, which is extremely important because chromatin abnormalities have repercussions on sperm quality and male fertility. Additionally, sperm DNA damage is strongly correlated with the mutagenic effects of cryopreservation. The viability of spermatozoa drops significantly after cryopreservation with respect to that of fresh sperm. The study of such cryo-changes using molecular biological methods will certainly help in the development of more efficient technologies for spermatozoon cryopreservation. It is also known that the cryo-biological properties of spermatozoa can change during the process of spermatogenesis. For example, a direct correlation is expected between the synthesis of proteins (natural cryoprotectants) and the cryo-properties of spermatozoa. Thus, this Special Issue of the journal is devoted not only to research directly related to the cryopreservation of cells, but also to the study of the characteristics of spermatogenesis, theoretically associated with the cryo-resistance of spermatozoa.
Dr. (SU) Vladimir Isachenko
Dr. Marc Yeste
Manuscript Submission Information
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