Special Issue "Epigenetic Regulation in Human Brain"
Deadline for manuscript submissions: closed (30 April 2021).
Interests: neurobiology; epigenetics; molecular biology; DNA methylation; DNA hydroxymethylaion; neuropsychiatric disorders; flow cytometry; high-throughput sequencing
The human brain is an organ of enormous complexity, composed of a multitude of cell types, including various populations of neuronal and glial cells. Epigenetics has been recognized for a long time as a group of molecular mechanisms that are essential in establishing and maintaining this complexity. Understanding the epigenetics of brain cell types is also necessary to uncover the mechanisms underlying nervous system disorders, which often display cell type-specific aetiology. However, in recent years, a number of methodological advances have allowed us to study brain epigenetics at cell-type resolution for the first time and brought the recognition of often vast and unexpected differences between the epigenomic profiles of brain cell populations. Despite this fast and promising progress, the field is currently wide open for new insights and discoveries, especially in the studies of brain development, disease, and ageing. A significantly more thorough understanding of neuroepigenetic mechanisms is also needed before we can efficiently transfer this line of research to the stage of therapeutic opportunities. In this Special Issue, we will highlight modern developments in the field of neuroepigenetics of human brain cell populations, in its relationship to brain development, health, and disease.
Dr. Alexey Kozlenkov
Manuscript Submission Information
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- DNA methylation
- histone modifications
- human brain
- glutamatergic neurons