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Special Issue "Epigenetic and Transcriptional Networks in Soft Tissue Sarcomas"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Rossella Rota
E-Mail Website
Guest Editor
Department of Oncohematology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Interests: Rhabdomyosarcoma; Pediatric soft tissue sarcomas; Epigenetics; Epigenetic drugs; Targeted therapy; Gene transcription; Chromatin modifiers; Diagnostic and prognostic
Prof. Dr. Francesco Marampon
E-Mail Website
Guest Editor
Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
Interests: Radiotherapy; Radio-resistance; Rhabdomyosarcoma; Adult cancers; Epigenetic drugs; Targeted therapy; ERK functions; MYC
Dr. Matteo Cassandri
E-Mail Website1 Website2
Guest Editor
Department of Oncohematology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Interests: Radiotherapy; Rhabdomyosarcoma; Epigenetics; Transcription regulation; Tumor genetics; Targeted therapy
Dr. Silvia Pomella
E-Mail Website
Guest Editor
Department of Oncohematology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Interests: Drug resistance; Rhabdomyosarcoma; Epigenetics; Transcriptional regulation; Pharmacogenomics; Targeted therapy

Special Issue Information

Dear Colleagues,

Soft tissue sarcomas (STSs) are a group of rare malignant tumors arising within embryonic mesenchymal tissues giving rise to cartilage, muscle, blood vessels, nerves and fat.

More than 50 subtypes of STSs have been identified, some preferentially affecting children while others affect adults.

STSs are highly heterogeneous at cellular and genomic levels, including subgroups mainly characterized by chromosomal translocations or genomic abnormalities and others with low levels of genomic alteration.

Despite advances in therapeutic approaches over the last several decades, local tumor control is difficult to achieve in aggressive forms and the outcome for metastatic patients still remains poor.

Recent increased knowledge of the primary molecular and genomic mechanisms in different STSs subtypes has often allowed for tumor reclassification, paving the way for the better stratification of patients and innovative targeted therapies.

Furthermore, the advent of new technologies promoted the genome-wide identification of epigenetic and transcriptional alterations associated to STSs subtypes. Altered gene expression driven by epigenetic remodelers and transcriptional regulators has been involved in key biological pathways in STSs. The identification of dysregulations at epigenetic and transcriptional levels that confer therapeutic vulnerabilities is offering novel biomarkers and therapeutic targets that can help in improving clinical management.

This Special Issue welcomes high-quality original research and review articles on basic and translational research focusing on innovative insights into epigenetic and transcriptional regulatory networks in adult and pediatric STSs.

Collectively, these findings may uncover new mechanisms of STSs’ pathogenesis and progression, providing new approaches to improve patient outcome impacting radio and drug resistance.

Dr. Rossella Rota
Prof. Dr. Francesco Marampon
Dr. Matteo Cassandri
Dr. Silvia Pomella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • soft tissue sarcoma
  • rhabdomyosarcoma
  • synovial sarcoma
  • leiomyosarcoma
  • angiosarcoma
  • fibrosarcoma
  • epithelioid sarcoma
  • gastrointestinal stromal tumor (GIST)
  • liposarcoma
  • malignant peripheral nerve sheath tumor (MPNST)
  • myxofibrosarcoma
  • solitary fibrous tumor
  • undifferentiated (pleomorphic sarcoma)
  • molecular genetics
  • epigenetics
  • transcription factors
  • gene expression
  • miRNA
  • lncRNA
  • histone modifications
  • DNA methylation
  • transcription
  • epigenetic drugs

Published Papers

This special issue is now open for submission.
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