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Special Issue "The Bidirectional Relationship between Cancer Epigenetics and Metabolism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. So Hee Kwon
E-Mail Website
Guest Editor
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea
Interests: cancer epigenetics; cancer metabolism; glioblastoma; ovarian cancer; pancreatic cancer; HDAC; KDM; HP1; p53
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of International Journal of Molecular Sciences focuses on the interplay between epigenetics and metabolism in physiological and pathological conditions.

Numerous studies have indicated that cellular metabolism and epigenetics are highly interconnected, contributing not only to physiological changes but also to numerous differnt human disorders and cancers. The epigenetic regulation of genes mediated by DNA- and histone-modifying enzymes (DNMT, HAT, HDAC, KAT, KDM, BET, etc.) is influenced by oncogene-mediated metabolic alterations. Such metabolic changes affect the presence or accesibility of cofactors that are required for the catalytic activity of epigenetic modifying enzymes. In addition, these metabolic alterations may produce oncometabolites that abnormally activate or inhibit such modifying enzymes, altering the epigenome. And, vice versa, epigenetic deregulation impacts metabolic gene expression in cancers, resulting in metabolomic alterations. As a result, the interplay between metabolism and epigenetics is crucial for the development of human diseases and tumorigenesis. Discovering novel molecular mechanisms linking the two pathways and targeting their downstream substrates could provide novel therapeutic targets to treat patients with different diseases.

In this issue, we are particularly interested in the regulation and mechanism of epigenetic enzymes and metabolic enzymes in cancer.

We warmly welcome submissions, including original research manuscripts and comprehensive reviews, on this exciting topic.

Dr. So Hee Kwon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer epigenetics
  • cancer metabolism
  • DNMT
  • ET
  • HAT
  • HDAC
  • KMT
  • KDM
  • metabolic enzymes
  • metabolic stress
  • oncometabolites
  • epigenetic enzyme inhibitors
  • cancer metabolism inhibitors

Published Papers

This special issue is now open for submission.
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