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Special Issue "Neuronal, Glial, and Immune Changes in Models of Epilepsy and Epileptogenesis-2nd Edition"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. Lee A. Shapiro
E-Mail Website
Guest Editor
Department of Surgery, Texas A & M University Health Science Center, College of Medicine, Temple, TX 76504, USA
Interests: neuroscience; neurodegenerative disorders; neuroimmune
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Epilepsy is one of the most common neurological disorders and affects people of all ages and genders. Epilepsy is defined as the recurrent appearance of seizures, and these seizures can be highly variable among individuals. Some types of epilepsy have predisposing, underlying factors, whereas others can be the result of injury or insult. Common themes in the development of epilepsy are changes to cellular, genetic, immune, anatomical, molecular, and physiological mechanisms, which ultimately result in the appearance of seizures and/or an increase in seizure susceptibility. This process of epileptogenesis can be highly unpredictable with regard to the timing, triggers, and specific mechanisms involved. Neurons and glial cells make up the fundamental cellular components of the central nervous system. The dysfunction of these cell types and the circuits to which they contribute can be pro-epileptogenic. A growing body of evidence also implicates inflammatory and neuroinflammatory mechanisms, as well as genetic and epigenetic factors in the development of epilepsy. Here, we seek manuscripts and review articles that pertain to cellular and immune contributions to seizures, epileptogenic progression, and the development of epilepsy. Studies that incorporate wide-ranging models, including injury models, are encouraged.

Prof. Dr. Lee A. Shapiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Epilepsy
  • Epileptogenesis
  • Seizure
  • Traumatic brain injury
  • Post-traumatic epilepsy
  • Injury
  • Neurons
  • Glia
  • Astrocyte
  • Microglia
  • Inflammation
  • Neuroinflammation
  • Cytokines
  • Immune
  • Neuroimmune
  • Neuroimmunity
  • B-cells
  • T-cells
  • Macrophage
  • Lymphocyte
  • Hyperexcitable

Published Papers

This special issue is now open for submission.
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