Special Issue "The Role of the Extracellular Matrix Molecules in Skeletal Muscle Regeneration"
Deadline for manuscript submissions: 30 November 2021.
Interests: skeletal muscle regeneration; stem cell niche; extracellular matrix; heterocellular connections; interstitial cells;
2. Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania
Interests: muscular dystrophy; musculoskeletal regeneration; molecular pathology; pathology; diagnosis of muscular dystrophy; immunohistochemistry; western blot; molecular evaluation; MLPA; ddPCR; RT-qPCR; therapeutic model for muscular dystrophy; extracellular matrix; dystrophin;.
2. Pathology Department - Research Center, Colentina Clinical Hospital, Bucharest, Romania
Interests: skeletal muscle; peripheral nerve pathology; experimental myology; neuroscience;
By virtue of its main function, the skeletal muscle is subjected to repeated mechanical stress caused by contraction–relaxation cycles, while its superficial distribution places it as the primary cushion against physical impact. Due to its impressive regeneration potential, functional recovery is the usual outcome. However, more severe injuries due to either injury, sarcopenia, or various diseases, including myositis and genetic defects, cause myofiber necrosis and tissue fibrosis.
The regeneration of skeletal muscle fibres following cell death relies mainly on the activation, proliferation and fusion of local stem cells called satellite cells (STC).
An important role in muscle regeneration and functional recovery is played by the extracellular matrix (ECM), synthesized by local and migrated interstitial cells. Though its structural proteins such as collagen, proteoglycans, glycoproteins, as well as growth factors and cytokines, the ECM offers the proper microenvironment for resident STC preservation, activation, migration and differentiation, and overall functional recovery. This Special Issue aims to highlight the molecular changes of the interstitial space during skeletal muscle regeneration, focusing on the activity of interstitial cells in synthesizing ECM molecules and controlling ECM composition, which could impact myogenesis in both healthy and diseased tissue.
Dr. Laura Cristina Ceafalan
Dr. Gisela Gaina
Dr. Emilia Manole
Manuscript Submission Information
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- skeletal muscle
- extracellular matrix
- muscle regeneration
- interstitial cells
- satellite cell niche
- extracellular matrix molecules