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Special Issue "The Role of the Extracellular Matrix Molecules in Skeletal Muscle Regeneration"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Laura Cristina Ceafalan
E-Mail Website
Guest Editor
"Carol Davila" University of Medicine and Pharmacy and Victor Babes Institute of Pathology from Bucharest, Bucharest, Romania
Interests: skeletal muscle regeneration; stem cell niche; extracellular matrix; heterocellular connections; interstitial cells;
Dr. Gisela Gaina
E-Mail Website
Guest Editor
1. Victor Babes National Institute of Pathology, Bucharest, Romania
2. Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania
Interests: muscular dystrophy; musculoskeletal regeneration; molecular pathology; pathology; diagnosis of muscular dystrophy; immunohistochemistry; western blot; molecular evaluation; MLPA; ddPCR; RT-qPCR; therapeutic model for muscular dystrophy; extracellular matrix; dystrophin;.
Dr. Emilia Manole
E-Mail Website
Guest Editor
1. Laboratory of Cell Biology, Neuroscience and Experimental Myology, "Victor Babeș" National Institute of Pathology, Bucharest, Romania
2. Pathology Department - Research Center, Colentina Clinical Hospital, Bucharest, Romania
Interests: skeletal muscle; peripheral nerve pathology; experimental myology; neuroscience;

Special Issue Information

Dear Colleagues,

By virtue of its main function, the skeletal muscle is subjected to repeated mechanical stress caused by contraction–relaxation cycles, while its superficial distribution places it as the primary cushion against physical impact. Due to its impressive regeneration potential, functional recovery is the usual outcome. However, more severe injuries due to either injury, sarcopenia, or various diseases, including myositis and genetic defects, cause myofiber necrosis and tissue fibrosis.

The regeneration of skeletal muscle fibres following cell death relies mainly on the activation, proliferation and fusion of local stem cells called satellite cells (STC).

An important role in muscle regeneration and functional recovery is played by the extracellular matrix (ECM), synthesized by local and migrated interstitial cells. Though its structural proteins such as collagen, proteoglycans, glycoproteins, as well as growth factors and cytokines, the ECM offers the proper microenvironment for resident STC preservation, activation, migration and differentiation, and overall functional recovery. This Special Issue aims to highlight the molecular changes of the interstitial space during skeletal muscle regeneration, focusing on the activity of interstitial cells in synthesizing ECM molecules and controlling ECM composition, which could impact myogenesis in both healthy and diseased tissue.

Dr. Laura Cristina Ceafalan
Dr. Gisela Gaina
Dr. Emilia Manole
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • skeletal muscle
  • extracellular matrix
  • myopathies
  • muscle regeneration
  • sarcopenia
  • interstitial cells
  • satellite cell niche
  • extracellular matrix molecules

Published Papers

This special issue is now open for submission.
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