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Special Issue "Role of Extracellular Matrix Molecules in CNS Injury, Aging and Neurodegenerative Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Jiří Růžička
E-Mail Website
Guest Editor
Institute of Experimental Medicine of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
Interests: spinal cord injury; aging; Alzheimer’s disease; neurodegeneration; regeneration and plasticity; extracellular matrix; perineuronal nets; memory and learning

Special Issue Information

Dear Colleagues,

In the central nervous system, the composition of the extracellular matrix (ECM) plays a crucial role in almost every step of cellular interactions, from the regulation of diffusion parameters and neuronal excitability to inhibition/activation of synaptic plasticity and axonal growth. All ECM structures, including perisynaptic, perinodal matrix or perineuronal nets (PNNs), respond to neuronal and glial activity in processes of memory and learning. Specialized structures such as PNNs enwrap mostly parvalbumin positive inhibitory interneurons and serve as a neuroprotective barrier and a way to stabilize already established neuronal circuits. Within the processes of aging, after CNS injury or in the progress of neurodegenerative disease, alternation in composition and structure of the ECM niche is significant. This results in an environment which is inhibitory to axonal growth or shows disbalance in synaptic plasticity. Enzymatic digestion experimental therapies and individual/multiple components knockouts have been shown to increase plasticity and regenerative potential under these circumstances and, in cases of neurodegenerative disorders, to reduce memory and learning deficiencies. The role of individual components of ECM, their alteration or their surface modifications is of long-term interest.

Dr. Jiří Růžička
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • extracellular matrix
  • perineuronal nets
  • spinal cord injury
  • traumatic brain injury
  • neurodegeneration
  • aging

Published Papers

This special issue is now open for submission.
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