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Fish Models and Neural Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 2588

Special Issue Editor

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia
Interests: neural stem cells; regeneration; neural development; brain and spinal cord injury; zebrafish
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Zebrafish and other fish models have been instrumental in revealing the underlying genetics and cell biology that orchestrate the development of the central nervous system. Combining the genetics and cell biology with recent developments in imaging technology, genome editing, compound libraries, genetically encoded physiological sensors and behaviour analysis have put fish models at the forefront of integrative neurosciences  Fish models enable longitudinal studies from embryo to adult on how specific cells in central nervous system are produced contribute to the neural circuitry and shape specific behaviours. This special issue is focused on all aspects of neural development using fish models.

Dr. Jan Kaslin
Guest Editor

Manuscript Submission Information

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Keywords

  • Fish
  • Neural development
  • Embryo
  • CNS
  • Integrative neuroscience

Published Papers (1 paper)

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Research

19 pages, 2429 KiB  
Article
Cerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner
by Cheng-Yung Lin, Hsiang-Chien Tseng, Yu-Rong Chu, Chia-Lun Wu, Po-Hsiang Zhang and Huai-Jen Tsai
Int. J. Mol. Sci. 2022, 23(8), 4150; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23084150 - 08 Apr 2022
Cited by 5 | Viewed by 2230
Abstract
Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons. While extracellular Pgk1 (ePgk1) is reported to promote neurite outgrowth, it remains unclear if it can affect the survival of dopaminergic cells. To address this, we employed cerebroventricular microinjection (CVMI) to deliver [...] Read more.
Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons. While extracellular Pgk1 (ePgk1) is reported to promote neurite outgrowth, it remains unclear if it can affect the survival of dopaminergic cells. To address this, we employed cerebroventricular microinjection (CVMI) to deliver Pgk1 into the brain of larvae and adult zebrafish treated with methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a PD-like model. The number of dopamine-producing cells in ventral diencephalon clusters of Pgk1-injected, MPTP-treated embryos increased over that of MPTP-treated embryos. Swimming distances of Pgk1-injected, MPTP-treated larvae and adult zebrafish were much longer compared to MPTP-treated samples. The effect of injected Pgk1 on both dopamine-producing cells and locomotion was time- and dose-dependent. Indeed, injected Pgk1 could be detected, located on dopamine neurons. When the glycolytic mutant Pgk1, Pgk1-T378P, was injected into the brain of MPTP-treated zebrafish groups, the protective ability of dopaminergic neurons did not differ from that of normal Pgk1. Therefore, ePgk1 is functionally independent from intracellular Pgk1 serving as an energy supplier. Furthermore, when Pgk1 was added to the culture medium for culturing dopamine-like SH-SY5Y cells, it could reduce the ROS pathway and apoptosis caused by the neurotoxin MPP+. These results show that ePgk1 benefits the survival of dopamine-producing cells and decreases neurotoxin damage. Full article
(This article belongs to the Special Issue Fish Models and Neural Development)
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