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Special Issue "Functional Food Components, Gut Microbiota Metabolism and Cardiometabolic Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Dr. Carolina Simó
E-Mail Website
Guest Editor
Laboratory of Molecular Nutrition and Metabolism. Institute of Food Science Research (CIAL), Spanish National Research Council (CSIC), Madrid 28049, Spain
Interests: nutritional metabolomics; gut microbiota; MS-based technologies; bioinformatics
Special Issues and Collections in MDPI journals
Dr. Virginia Garcia-Cañas
E-Mail Website
Guest Editor
Laboratory of Molecular Nutrition and Metabolism. Institute of Food Science Research (CIAL), Spanish National Research Council (CSIC), Madrid 28049, Spain
Interests: molecular nutrition; gut microbiota metabolism; metagenomics; next-generation sequencing; bioinformatics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The intestinal microbial metabolism is a fundamental part of host metabolism and physiology. A range of microbial metabolites have been described to affect the function of distant organs. Scientific evidence suggests that the metabolism of resident microbiota in the gut may have a crucial role in health maintenance, and its alteration as a result of changes in microbiota structure and function may be accompanied by disordered physiological processes in the host. In the last years, number of studies have shown that the gut microbiota is closely related to cardiometabolic diseases, including cardiovascular disease, obesity, diabetes mellitus, and non-alcoholic fatty liver disease.  Diet may affect the intestinal homeostasis by altering the microbial community, and consequently, the associated microbial metabolome with potential beneficial or harmful effects. Thus, dietary intervention may represent an important strategy to modulate the gut microbiota and its metabolic function for health maintenance as well as disease prevention. In this context, the search for bioactive compounds from edible natural sources with the potential to target the gut microbiota constituents and/or its metabolic capacity offers great opportunities to devise novel functional foods to improve health. In this area of research there is an increasingly number of important unsolved questions such as how certain microbial metabolites contribute to disease, how the microbiota can be shaped to prevent or alter the progression of a disease, or how inter-individual variations in gut microbiota impact the effect of bioactive food compounds, among others. Advances in this area are expected to be fueled by the increasingly growing application of next-generation sequencing and other omics technologies. With regard to this, a shift from studies focusing on describing microbial community composition to more function-oriented research on gut microbiota is expected. Thus, shot-gun metagenomics, meta-transcriptomics, meta-proteomics, metabolomics and bioinformatics will have a key role to unravel the complex links among diet, microbial metabolism and host health. Thus, a better understanding of the relationships between diet, gut microbiota and cardiometabolic health may help to improve the prevention and treatment of certain cardiometabolic diseases.

The topics that will be covered by this Special Issue include:

- Link between diet, microbial metabolism and cardiovascular diseases, obesity, diabetes mellitus, non-alcoholic fatty liver diseases, etc.

- Relationship between specific gut microbial metabolites and cardiovascular diseases, obesity, diabetes mellitus, non-alcoholic fatty liver diseases, etc.

- Association of microbial-derived metabolite levels with foods and dietary patterns.

- Evaluation and discovery of novel dietary precursors of relevant microbial metabolites.

- Metabolic fate of dietary precursors of microbial metabolites.

- Dietary strategies to modulate circulating microbial-derived metabolite levels.

- Effect of bioactive compounds from natural sources to modulate microbial metabolite generation.

- Influence of gut microbial activity on the availability and bioactivity of dietary compounds.

- Microbiota-mediated mechanisms of the effect of bioactive dietary constituents on microbial metabolite levels.

- Influence of inter-individual variation in the physiological effects of bioactive food compounds due to variation in the gut microbiota.

- Meta-omics approaches to study the interplay of food or bioactive food compounds with the gut microbiota in the context of particular diseases.

Dr. Carolina Simó
Dr. Virginia Garcia-Cañas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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