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Special Issue "GABAergic and GLUTamatergic Systems in Fronto Temporal Dementia"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Dr. Patrizia Longone
E-Mail Website
Guest Editor
Molecular Neurobiology Unit, IRCCS-Fondazione Santa Lucia, 00143 Rome, Italy
Interests: Apoptosis; Inflammation, Hydrogen Sulfide; Motor Neuron; Astrocytes
Special Issues and Collections in MDPI journals
Dr. Emanuele Buratti
E-Mail Website
Guest Editor
International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
Interests: https://www.researchgate.net/profile/Emanuele_Buratti

Special Issue Information

Dear Colleagues,

This Special Issue is focused on the effort to sum up current knowledge on the role of neurotransmitter systems (particularly GABAergic and Glutamatergic) in frontotemporal dementia (FTD).

Degenerative cortical dementias are the most common form of debilitating dementias, making them the largest independent contributor of any chronic disease to require care. It is estimated that the global dementia burden will double by 2021. Among dementias, FTD is a heterogeneous clinical syndrome that principally affects the frontal and temporal lobes of the brain, characterized by progressive changes in behavior, personality, and/or language. After Alzheimer's disease, it is the most common cause of dementia, particularly in individuals younger than 65 years. FTD comprises major clinical subtypes and is often associated with movement abnormalities, including atypical parkinsonism or motor neuron disease (MND), with up to half of ALS patients found to have evidence of frontal lobe impairment. Three major genes are recognized to play an important role in the autosomal dominant form: progranulin (GRN), chromosome 9 open reading frame 72 (C9orf72), and microtubule-associated protein tau (MAPT). Clinically, FTD spectrum is categorized into three syndromes: (i) behavioral variant (bvFTD), with a progressive decline in behavior and executive function, associated to a frontal lobe-predominant atrophy, with or without motor neuron disease (MND); (ii) semantic dementia (SD), characterized by a loss of semantic knowledge, associated with an atrophy of the left greater than right anterior temporal lobe; and (iii) progressive non-fluent aphasia (PNFA), presenting expressive or motor speech deficits, with predominantly left peri-sylvian atrophy.

Many novel biological mechanisms leading to FTD have been identified. Nevertheless, the cause remains elusive, and many questions are still unanswered. Why are the frontal and temporal lobes of the brain so vulnerable in FTD? How does FTD spread in the brain? Changes in the neurotransmitter systems might provoke morphological and functional alterations in the cortical environment, leading to neuronal degeneration. 

The Special Issue welcomes original research manuscripts, short communications, and reviews on the latest progresses uncovering mechanisms linked to an unbalanced ratio of the excitation/inhibition pathways in FTD.

Dr. Patrizia Longone
Dr. Emanuele Buratti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • GABA
  • Glutamate
  • Neurotransmitters
  • Frontotemporal dementia
  • Motor neuron disease
  • Cortical networks
  • Disinhibition

Published Papers

This special issue is now open for submission.
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