Special Issue "Growth Hormone (GH): Multiple Therapeutic Possibilities and Molecular Mechanisms of Action 2.0"
Deadline for manuscript submissions: 31 July 2021.
Interests: growth hormone; growth hormone receptor; IGF-I; brain injury; stroke; cerebral palsy; hypoxia/ischemia; neurodegeneration; atherosclerosis; growth hormone and gonads; growth hormone and diabetes; growth hormone and cancer; growth hormone signaling pathway
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Classically, GH has been considered to be a pituitary hormone, with predominantly metabolic actions and an effect on the longitudinal growth of that organism until the end of puberty. However, today, we know that GH is expressed in virtually all tissues and organs of the human body, in which it plays a self/paracrine role—possibly, although it is not known—in cooperation with hormones from the plasma after being released by the pituitary gland. We also know that after interacting with its membrane receptor, GH is internalized together with the GHR, a mechanism that allows the GHR to be translocated to the nucleus of cells for inducing or blocking gene expression; we also know that, at least in rodents, internalized GH undergoes a proteolytic break (tissue, sex, and age-specific), giving rise to shorter peptides whose functions are still unknown. Since the beginning of the 2000s, when it was discovered that the GHR was upregulated in the brain of rodents after induced brain damage, interest in the possible actions of GH in the repair of the brain has continued to increase. The same is true with respect to the effects of the hormone on the vascular endothelium, where GH seems to have a beneficial effect, or in the gonads, where a local GH/IGF-I axis seems to play a key role in the physiological gonadal function. The effects of GH on the beta cells of the islets of Langerhans and diabetes need to be clarified, as well as the relationships between GH and cancer. Furthermore, GH signaling pathways in different tissues must be elucidated, and the same is true of the induction by GH of the expression of many different growth factors.
Giving an answer to these molecular mechanisms of action, still unknown or poorly understood, and the relationships between GH and other growth factors will provide a better understanding of the effects of this important hormone, for its therapeutic use in many different pathologies beyond its mere use for growth in GH-deficient children.
For these reasons, researchers are invited to submit their original research or reviews for this Special Issue of the International Journal of Molecular Sciences, entitled "Growth Hormone (GH): Multiple Possibilities and Molecular Mechanisms of Action", which will cover a selection of topics highlighting the role of GH and its molecular effects in health (included aging) and therapeutic possibilities.
Prof. Dr. Jesús Devesa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Growth Hormone
- GH/IGF-I axis