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Molecular Mechanisms and Targeted Therapies in Gastrointestinal Cancers
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Molecular Mechanisms and Targeted Therapies in Gastrointestinal Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 3217

Special Issue Editors

Prof. Dr. Sara Lonardi

E-Mail Website
Guest Editor
Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy
Interests: oncology; target therapy; MSI; gastrointestinal oncology; colorectal cancer
Prof. Dr. Matteo Fassan

E-Mail Website
Guest Editor
Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Via Giustiniani, 35128 Padua, Italy
Interests: colorectal cancer; gastric cancer; dysplasia; molecular carcinogenesis; predictive biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of gastrointestinal cancers, resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling. Concurrently, the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced tumors. This Special Issue will focus on both the molecular characterization and innovative molecularly-based targeted therapies in metastatic gastrointestinal tumors.

Prof. Dr. Sara Lonardi
Prof. Dr. Matteo Fassan

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Gastrointestinal oncology
  • Target therapy
  • Immunotherapy
  • Molecular biomarkers

Published Papers (1 paper)

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Research

17 pages, 3934 KiB  
Article
Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells
by Thinh-Thi Nguyen, Thuan-Trong Ung, Shinan Li, Dhiraj Kumar Sah, Sun-Young Park, Sen Lian and Young-Do Jung
Int. J. Mol. Sci. 2021, 22(19), 10209; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910209 - 22 Sep 2021
Cited by 11 | Viewed by 2779
Abstract
Micro-RNA-21 (miR-21) is a vital regulator of colorectal cancer (CRC) progression and has emerged as a potential therapeutic target in CRC treatment. Our study using real-time PCR assay found that a secondary bile acid, lithocholic acid (LCA), stimulated the expression of miR21 in [...] Read more.
Micro-RNA-21 (miR-21) is a vital regulator of colorectal cancer (CRC) progression and has emerged as a potential therapeutic target in CRC treatment. Our study using real-time PCR assay found that a secondary bile acid, lithocholic acid (LCA), stimulated the expression of miR21 in the CRC cell lines. Promoter activity assay showed that LCA strongly stimulated miR21 promoter activity in HCT116 cells in a time- and dose-dependent manner. Studies of chemical inhibitors and miR21 promoter mutants indicated that Erk1/2 signaling, AP-1 transcription factor, and STAT3 are major signals involved in the mechanism of LCA-induced miR21 in HCT116 cells. The elevation of miR21 expression was upstream of the phosphatase and tensin homolog (PTEN) inhibition, and CRC cell proliferation enhancement that was shown to be possibly mediated by PI3K/AKT signaling activation. This study is the first to report that LCA affects miR21 expression in CRC cells, providing us with a better understanding of the cancer-promoting mechanism of bile acids that have been described as the very first promoters of CRC progression. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Targeted Therapies in Gastrointestinal Cancers)
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