Dear Colleagues,

Gastrointestinal (GI) malignancies comprise a group of cancer types, divided by primary site and clinical characteristics, but often sharing similar driving mechanisms. Better stratification and understanding the molecular events that drive these tumors is critical in order to inhibit their development, growth and metastatic spread. Accumulating genomic data provided invaluable information regarding type and frequency of genomic alterations in GI malignancies. However, the mechanistic roles of these alterations are, in most parts, not well defined.

This issue will focus on personalized approach to GI malignancies. We seek high quality manuscripts describing the role of genomic alterations in mediating tumor aggressiveness and metastases formation; the path from genomic alterations to transcriptomic and metabolomic characteristics and the road to resistance therapy.

We specifically encourage the submission of manuscripts presenting innovative approaches exploiting these data in an attempt to identify novel strategies to inhibit tumor growth and spread and overcome resistance to current therapies.

Prof. Dr. Fabio Grizzi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Genomic alterations 
• Metastases formation 
• Transcriptional regulation 
• Tumor metabolism 
• Targeted therapy 
• Acquired resistance