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Special Issue "Regulation of Gene Expression during Embryonic Development 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Adam Davis
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Guest Editor
Department of Biology, University of North Georgia, 3820 Mundy Mill Road, Oakwood, GA 30566, USA
Interests: Developmental Biology
Special Issues and Collections in MDPI journals
Dr. Jo Qian
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Guest Editor
Department of Biology, University of North Georgia, 3820 Mundy Mill Road, Oakwood, GA 30566, USA
Interests: Developmental Biology
Special Issues and Collections in MDPI journals
Dr. Ghulam Hasnain
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Guest Editor
Department of Biology, University of North Georgia, 3820 Mundy Mill Road, Oakwood, GA 30566, USA
Interests: Gene Expression
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of the International Journal of Molecular Science shall encompass topics regarding the evolution of regulation of gene expression during eukaryotic embryonic development. Topics may include but not be limited to the evolution of differential gene expression at the level of transcription, mRNA processing, translation, and/or subcellular localization of protein expression. Further, data on how mutations at the level of the DNA have led to divergent gene regulation mechanisms, genetic regulatory networks, and/or the development of variable morphological structures between evolutionarily divergent lineages are acceptable. Research manuscripts and comprehensive reviews adhering to the journal’s aims will be accepted.

Dr. Adam Davis
Dr. Jo Qian
Dr. Ghulam Hasnain
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway
Int. J. Mol. Sci. 2021, 22(11), 5915; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115915 - 31 May 2021
Viewed by 651
Abstract
The segregation of trophectoderm (TE) and inner cell mass in early embryos is driven primarily by the transcription factor CDX2. The signals that trigger CDX2 activation are, however, less clear. In mouse embryos, the Hippo-YAP signaling pathway is important for the activation of [...] Read more.
The segregation of trophectoderm (TE) and inner cell mass in early embryos is driven primarily by the transcription factor CDX2. The signals that trigger CDX2 activation are, however, less clear. In mouse embryos, the Hippo-YAP signaling pathway is important for the activation of CDX2 expression; it is less clear whether this relationship is conserved in other mammals. Lysophosphatidic acid (LPA) has been reported to increase YAP levels by inhibiting its degradation. In this study, we cultured bovine embryos in the presence of LPA and examined changes in gene and protein expression. LPA was found to accelerate the onset of blastocyst formation on days 5 and 6, without changing the TE/inner cell mass ratio. We further observed that the expression of TAZ and TEAD4 was up-regulated, and YAP was overexpressed, in LPA-treated day 6 embryos. However, LPA-induced up-regulation of CDX2 expression was only evident in day 8 embryos. Overall, our data suggest that the Hippo signaling pathway is involved in the initiation of bovine blastocyst formation, but does not affect the cell lineage constitution of blastocysts. Full article
(This article belongs to the Special Issue Regulation of Gene Expression during Embryonic Development 2.0)
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