Special Issue "The Role of Genetic Variation on Transcription Factor Binding Sites in Evolution and Disease"
Deadline for manuscript submissions: 30 November 2021.
Interests: Neuroscience; Human Evolution; Herpesviruses; Neurodevelopment; Functional Genomics
The genetic bases of many human diseases and phenotypic evolutionary changes most frequently implicate regulatory elements, and one important type of functional element among those are transcription factor binding sites (TFBSs). The study of disease susceptibility or evolutionary changes derived from variation in TFBSs is of great interest but challenging, as it requires the extracting of inferences from very short and sometimes intrinsically degenerated transcription factor motifs.
This Special Issue will highlight in silico and experimental approaches to study the contribution of genetic polymorphisms that create or disrupt TFBSs in disease and in evolution. This includes topics related to molecular evolution, regulatory sequences and both in silico and experimental analyses on transcription factor binding sites.
Dr. Gabriel Santpere
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- molecular evolution
- transcription factor binding sites
- regulatory elements
- noncoding DNA
- developmental disorders