Special Issue "Molecular Mechanisms Safeguarding Genome Integrity in DNA Replication, Repair and Transcription"
Deadline for manuscript submissions: 31 December 2021.
Interests: DNA damage response (DDR); DNA repair and cell cycle checkpoints; p21(CDKN1A)/PCNA interaction; nucleotide excision repair/base excision repair; post-translational modifications of DNA repair factors; acetylation deficiency and human disease
Interests: Cancer Biology; Experimental Medicine
In recent years, knowledge on the cellular and molecular mechanisms underlying the maintenance of genome integrity has increased significantly through the identification of the signaling pathways and main players in the DNA damage response. Thanks to these advancements, crucial aspects of this important cell defense mechanism are currently being exploited, and new strategies to control abnormal cell proliferation and tumor formation are being developed. However, refined definitions of the processes involved in the DNA damage response, especially regarding their regulation, are needed to further this knowledge and identify new points of intervention. In particular, protein–protein interactions, as well as protein post-translation modifications are important components in unravelling the mechanisms responsible for the maintenance of genome stability. This Special Issue will focus on the latest research in the essential processes of DNA replication, repair, and transcription with the aim of advancing the knowledge of the roles of these molecular mechanisms in the DNA damage response.
Dr. Ornella Cazzalini
Dr. Ennio Prosperi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA damage and repair
- DNA replication stress
- transcription stress
- genome stability
- protein–protein interactions
- post-translational modifications
- phosphorylation, acetylation, ubiquitination, poly(ADP)-ribosylation