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Special Issue "Glial-Neuronal Interactions in Neurological Disorders: Molecular Mechanisms and Potential Points for Intervention 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Agata Adamczyk
E-Mail Website
Guest Editor
Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
Interests: neurodegeneration; neuroinflammation; mitochondria failure; autism spectrum disorders; synaptic plasticity; signal transduction; oxidative/nitrosative stress; alpha-synuclein
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The central nervous system (CNS) function depends on both neurons and glial cells, and the interactions between these cells play critical roles in the functionality of the healthy CNS. However, genetic, molecular, and epidemiologic studies have also revealed the prominent and often causative roles of glial–neuronal interactions in the development or progression of many common neurodegenerative and neurodevelopmental disorders, including: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ischemia (stroke), multiple sclerosis, epilepsy, schizophrenia, as well as autism-spectrum disorders. Accumulation of misfolded proteins, impairment in protein trafficking and energy metabolism, oxidative stress, and formation of free radicals are common features for these pathological conditions. All these pathways are strongly regulated by glial cells in the CNS that are responsible for maintaining homeostasis on the cellular, metabolic, structural, and signaling transmission level. Therefore, the main goal of this Special Issue is to reveal directions and consequences of glial–neuronal interactions for improving our understanding of the pathomechanisms as well as for the development of potential new therapies for neurological disorders. Original manuscripts and reviews dealing with the implication of glial–neuronal interactions in the development or progression of neurodegenerative and neurodevelopmental disorders are very welcome from outstanding experts on the topic.

Dr. Agata Adamczyk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Central nervous system
  • Glial–Neuronal interactions
  • Autism spectrum disorders
  • Neurodegenerative disorders
  • Neurodevelopmental disorders
  • Neuroinflammation
  • Synapses
  • Signal transduction

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Published Papers

This special issue is now open for submission.
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