Special Issue "Glial Ion Channels and Transporters in Health and Disease"
Deadline for manuscript submissions: closed (30 April 2021).
The first description of neurons and glia is most likely synchronous. Indeed, in 1824, Henri Dutrochet reported for the first time two types of “globular corpuscules” in the ganglia of two species of mollusks: large ones (neurons) and associated smaller ones (glia). However, the concept of animal electricity had been introduced a few decades earlier by Galvani and so the study of the excitable cells of the nervous system took off, leaving the study of glia to lag. However, the 1950s started to see a surge of interest in glial cells, with a slow shift of paradigm from considering these cells as mere structural support to viewing them as major players in the function of the nervous system. In particular, the first voltage and current recordings by Coombs and colleagues (1955) and by Hillds (1958) revealed that glia are also endowed with ion channels. In the last 60+ years, we have made substantial progress in our understanding of the function of membrane proteins that mediate the transfer of ions in and out of glia, especially as it relates to neuronal output. Indeed, studies in isolated glial cells, in slices and in vivo showed that glial ion channels and transporters function in two main capacities: regulation of the ionic composition and regulation of the concentration of solutes including neurotransmitter, both by reuptake and release in the extracellular space. This Special Issue will be dedicated to highlighting research on glial ion channels and transporters that impact neuronal function and development in healthy physiology and pathology, welcoming studies that use model organisms such as C. elegans and Drosophila to decipher these functions.
Prof. Laura Bianchi
Manuscript Submission Information
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- ion channels
- ionic homeostasis
- neuronal function