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Special Issue "Neuroprotective Effect of Glutathione"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. Koji Aoyama
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Guest Editor
Department of Pharmacology, Teikyo University School of Medicine, Japan

Special Issue Information

Dear Colleagues,

More than 130 years have passed since glutathione (GSH) was discovered as "philothione" from yeast. There are many publications regarding the neuroprotective functions of GSH (as an antioxidant and/or redox buffer, etc.) in vivo and in vitro, while GSH depletion induces/exacerbates neuronal damage in the brain. The promotion of GSH functions would be a promising approach against neuronal death. The aim of this Special Issue is to provide feature articles of the most current findings related to GSH in the central nervous system. In this Special Issue, neurologic disorders based on molecular sciences related to GSH dysfunction are also encouraged.

Prof. Dr. Koji Aoyama
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (1 paper)

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Review

Open AccessReview
The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione
Int. J. Mol. Sci. 2021, 22(8), 4245; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084245 - 19 Apr 2021
Viewed by 283
Abstract
The establishment of antioxidative defense systems might have been mandatory for most living beings with aerobic metabolisms, because oxygen consumption produces adverse byproducts known as reactive oxygen species (ROS). The brain is especially vulnerable to the effect of ROS, since the brain has [...] Read more.
The establishment of antioxidative defense systems might have been mandatory for most living beings with aerobic metabolisms, because oxygen consumption produces adverse byproducts known as reactive oxygen species (ROS). The brain is especially vulnerable to the effect of ROS, since the brain has large amounts of unsaturated fatty acids, which are a target of lipid oxidation, as well as comparably high-energy consumption compared to other organs that results in ROS release from mitochondria. Thus, dysregulation of the synthesis and/or metabolism of antioxidants—particularly glutathione (GSH), which is one of the most important antioxidants in the human body—caused oxidative stress states that resulted in critical diseases, including neurodegenerative diseases in the brain. GSH plays crucial roles not only as an antioxidant but also as an enzyme cofactor, cysteine storage form, the major redox buffer, and a neuromodulator in the central nervous system. The levels of GSH are precisely regulated by uptake systems for GSH precursors as well as GSH biosynthesis and metabolism. The rapid advance of RNA sequencing technologies has contributed to the discovery of numerous non-coding RNAs with a wide range of functions. Recent lines of evidence show that several types of non-coding RNAs, including microRNA, long non-coding RNA and circular RNA, are abundantly expressed in the brain, and their activation or inhibition could contribute to neuroprotection through the regulation of GSH synthesis and/or metabolism. Interestingly, these non-coding RNAs play key roles in gene regulation and growing evidence indicates that non-coding RNAs interact with each other and are co-regulated. In this review, we focus on how the non-coding RNAs modulate the level of GSH and modify the oxidative stress states in the brain. Full article
(This article belongs to the Special Issue Neuroprotective Effect of Glutathione)
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