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Special Issue "The Glucosamine Derivatives for Human Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 January 2021).

Special Issue Editor

Dr. Roberto Scandurra

Guest Editor
Department of Biochemical Sciences, Sapienza University of Roma, Roma, Italy

Special Issue Information

Glucosamine (GlcN) plays  important roles in many biological tissues and in human  cardiovascular disease, neurological deficits, skin disorders, and cancer, but its major role is in cartilage extracellular matrix, where GlcN is the major constituent of macromolecules such as glycosaminoglycans (GAG), glycolipids, and glycoproteins, providing building blocks for their  biosynthesis. The latter is decreased in osteoartritis (OA) due to an imbalance between the synthesis and degradation of extracellular matrix (ECM) components, and the possible benefit of an external  supply of GlcN to replace the lost one. A further antiinflammatory action of GlcN and its ability to reduce  pain  in OA patients provided qualified GlcN as an chondroprotective agent that can be utilized to prevent or delay cartilage degradation. Accordingly, a large amount of research addressed to obtain GlcN derivatives to increase not only its palliative action on OA but also a possible curative action, since OA is actually a non-curable disease and its pharmacological treatment, is based mainly on analgesic agents or nonsteroidal anti-inflammatory drugs (NSAIDs).

Dr. Roberto Scandurra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Glucosamine derivatives in osteoarthritis
  • Glucosamine derivatives in cardiovascular disease
  • Glucosamine derivatives in neurological deficits
  • Glucosamine derivatives in skin disorders
  • Glucosamine derivatives in cancer

Published Papers

There is no accepted submissions to this special issue at this moment.
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