Special Issue "Glycome and Nervous System"
Deadline for manuscript submissions: 30 June 2021.
Interests: glycobiology and disease implication; glycosyltransferases involved in N-linked glycans; reactive oxygen species; glutathione metabolism
More than 70 % of proteins are modified with glycans; N-linked glycosylation to Asn residues, and O-linked glycosylation to Ser or Thr residues. In the brain, several adhesion molecules and receptor proteins are modified with specific glycans and these glycans play important roles for high-order brain function. a2,8-Linked polysialic acid (polySia) is found in the N-linked glycans of neural cell adhesion molecule, N-CAM, and is involved in cell-cell interaction during neural development and plasticity. Genome-wide association study shows that genetic variation of the polysialyltransferase gene associates with mental disorder. HNK-1 epitope is predominantly expressed in the brains, modifies the N-linked glycans of several neural proteins, such as myelin-associated glycoprotein (MAG), L1, and glutamate receptor, and has critical role for synaptic plasticity, spatial learning, and memory. Brain-specific b1,6-GlcNAc-branched O-mannosyl glycans decorate protein tyrosine phosphatase Z (PTPRZ), which is expressed in astrocytes and oligodendrocyte precursor cells. PTPRZ expression is markedly increased in brain tumors, and its shedding form in cerebrospinal fluid (CSF) is a promising diagnostic marker for glioma. In this Special Issue, we would explore how Nerve-specific glycans carry out their roles in neural development as well as interaction of nervous system and tumor environment.
Prof. Dr. Naoyuki Taniguchi
Prof. Dr. Shinobu Kitazume
Manuscript Submission Information
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- Polysialic acid
- O-mannose glycan
- neural activity
- Alzheimer’s disease
- neural development
- psychiatric disease