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Special Issue "Glycome and Nervous System"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Dr. Naoyuki Taniguchi
E-Mail Website
Guest Editor
Department of Glyco-Oncology, Research Center, Osaka International Cancer Institute, Osaka Japan, Professor Emeritus Osaka University
Interests: glycobiology and disease implication; glycosyltransferases involved in N-linked glycans; reactive oxygen species; glutathione metabolism
Prof. Dr. Shinobu Kitazume
E-Mail Website
Guest Editor
Fukushima University, Fukushima, Japan
Interests: glycoscience in brain and brain-related diseases; glycobiology in brain; sialic acid biosynthesis; biomarker discovery; Alzheimer’s disease

Special Issue Information

Dear colleagues,

More than 70 % of proteins are modified with glycans; N-linked glycosylation to Asn residues, and O-linked glycosylation to Ser or Thr residues. In the brain, several adhesion molecules and receptor proteins are modified with specific glycans and these glycans play important roles for high-order brain function. a2,8-Linked polysialic acid (polySia) is found in the N-linked glycans of neural cell adhesion molecule, N-CAM, and is involved in cell-cell interaction during neural development and plasticity. Genome-wide association study shows that genetic variation of the polysialyltransferase gene associates with mental disorder. HNK-1 epitope is predominantly expressed in the brains, modifies the N-linked glycans of several neural proteins, such as myelin-associated glycoprotein (MAG), L1, and glutamate receptor, and has critical role for synaptic plasticity, spatial learning, and memory. Brain-specific b1,6-GlcNAc-branched O-mannosyl glycans decorate protein tyrosine phosphatase Z (PTPRZ), which is expressed in astrocytes and oligodendrocyte precursor cells. PTPRZ expression is markedly increased in brain tumors, and its shedding form in cerebrospinal fluid (CSF) is a promising diagnostic marker for glioma. In this Special Issue, we would explore how Nerve-specific glycans carry out their roles in neural development as well as interaction of nervous system and tumor environment.

Prof. Dr. Naoyuki Taniguchi
Prof. Dr. Shinobu Kitazume
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Polysialic acid
  • HNK-1
  • O-mannose glycan
  • glycosylatransferases
  • neural activity
  • Alzheimer’s disease
  • neural development
  • psychiatric disease
  • glioma

Published Papers

This special issue is now open for submission.
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