Special Issue "Role of the Hypothalamo–Pituitary–Adrenal (HPA) Axis in Health and Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2017).
This Special Issue will include a selection of recent research topics and current review articles related to the role of the hypothalamic–pituitary–adrenal (HPA) axis in health and disease. Up-to-date review articles, commentaries and experimental papers are all welcome.
The HPA axis describes a complex set of positive and negative feedback influences between the hypothalamus, pituitary gland, and adrenal gland. These positive and negative feedback mechanisms work in a neuroendocrine manner in order to modulate a number of physiological processes such as immunity, digestion, and the body’s response to stress.
The mechanism by which the HPA axis remains in homeostasis depends widely on the release and uptake of several key regulatory molecules. The hypothalamus contains neuroendocrine neurons that secrete corticotropin-releasing hormone (CRH). CRH will, in turn, act on the pituitary gland to stimulate the production and release of adrenocorticotropic hormone (ACTH) into the circulation. Circulating ACTH then induces the adrenal gland to synthesize and release corticosteroids, such as cortisol and corticosterone. These circulating corticosteroids modulate the vast array of physiological processes influenced by the HPA axis and are also responsible for initiating a negative feedback loop on the HPA axis via activation of the glucocorticoid receptor (GR) in the brain in order to shut down corticosteroid production. This axis is dysregulated in a number of pathologies.
This Special Issue will bring together a number of manuscripts delineating the various roles that the HPA axis plays in the pathology of different organs throughout the body in relation to a number of disease processes.
Dr. Sharon DeMorrow
Manuscript Submission Information
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- HPA axis